Biology:Prostaglandin-A1 Delta-isomerase
From HandWiki
| Prostaglandin-A1 Δ-isomerase | |||||||||
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| Identifiers | |||||||||
| EC number | 5.3.3.9 | ||||||||
| CAS number | 9055-01-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a Prostaglandin-A1 Δ-isomerase (EC 5.3.3.9) is an enzyme that catalyzes the chemical reaction
- (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate [math]\displaystyle{ \rightleftharpoons }[/math] (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate
Hence, this enzyme has one substrate, (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate (Prostaglandin A1 or PGA1), and one product, (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate (Prostaglandin C1).
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate Delta10-Delta11-isomerase. This enzyme is also called prostaglandin A isomerase.
References
- "Metabolism of prostaglandins E, A, and C in serum". J. Biol. Chem. 250 (2): 351–7. 1975. PMID 234423.
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