Biology:RAB5A

Short description: Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-5A is a protein that in humans is encoded by the RAB5A gene.^[1]^[2]

Function

RAB5A localizes to early endosomes where it is involved in the recruitment of RAB7A and the maturation of these compartments to late endosomes.^[3] It drives the maturation of endosomes by transporting vacuolar (H+)-ATPases (V-ATPases) from trans-Golgi network to endocytic vesicles.^[4]

Interactions

RAB5A has been shown to interact with:

CHML,^[5]^[6]
RABEP1,^[7]^[8]^[9]^[10]
SDCBP,^[11] and
ZFYVE20^[12]

References

↑ "Chromosome assignment of four RAS-related RAB genes". Human Genetics 86 (4): 350–4. Feb 1991. doi:10.1007/BF00201831. PMID 1999336.
↑ "Entrez Gene: RAB5A RAB5A, member RAS oncogene family". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5868.
↑ "Endosome maturation". The EMBO Journal 30 (17): 3481–500. Aug 2011. doi:10.1038/emboj.2011.286. PMID 21878991.
↑ "A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation". The Journal of Biological Chemistry 286 (11): 9373–81. Mar 2011. doi:10.1074/jbc.M110.207720. PMID 21252234.
↑ "Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex". Biochemistry 37 (36): 12559–68. Sep 1998. doi:10.1021/bi980881a. PMID 9730828.
↑ "REP-2, a Rab escort protein encoded by the choroideremia-like gene". The Journal of Biological Chemistry 269 (3): 2111–7. Jan 1994. doi:10.1016/S0021-9258(17)42142-9. PMID 8294464.
↑ "The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis". The Journal of Biological Chemistry 272 (10): 6097–100. Mar 1997. doi:10.1074/jbc.272.10.6097. PMID 9045618.
↑ "Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal 17 (7): 1941–51. Apr 1998. doi:10.1093/emboj/17.7.1941. PMID 9524117.
↑ "Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion". Cell 83 (3): 423–32. Nov 1995. doi:10.1016/0092-8674(95)90120-5. PMID 8521472.
↑ "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Letters 508 (2): 201–9. Nov 2001. doi:10.1016/s0014-5793(01)02993-3. PMID 11718716.
↑ "Role of Unc51.1 and its binding partners in CNS axon outgrowth". Genes & Development 18 (5): 541–58. Mar 2004. doi:10.1101/gad.1151204. PMID 15014045.
↑ "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain". The Journal of Cell Biology 151 (3): 601–12. Oct 2000. doi:10.1083/jcb.151.3.601. PMID 11062261.

"The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway". Cell 70 (5): 715–28. Sep 1992. doi:10.1016/0092-8674(92)90306-W. PMID 1516130.
"The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion". The Journal of Biological Chemistry 264 (21): 12394–401. Jul 1989. doi:10.1016/S0021-9258(18)63872-4. PMID 2501306.
"Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A". Proceedings of the National Academy of Sciences of the United States of America 91 (25): 11963–7. Dec 1994. doi:10.1073/pnas.91.25.11963. PMID 7991565. Bibcode: 1994PNAS...9111963F.
"REP-2, a Rab escort protein encoded by the choroideremia-like gene". The Journal of Biological Chemistry 269 (3): 2111–7. Jan 1994. doi:10.1016/S0021-9258(17)42142-9. PMID 8294464.
"Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion". Cell 83 (3): 423–32. Nov 1995. doi:10.1016/0092-8674(95)90120-5. PMID 8521472.
"Subcellular localization of the small GTPase Rab5a in resting and stimulated human neutrophils". Experimental Cell Research 227 (2): 367–73. Sep 1996. doi:10.1006/excr.1996.0286. PMID 8831575.
"The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis". The Journal of Biological Chemistry 272 (10): 6097–100. Mar 1997. doi:10.1074/jbc.272.10.6097. PMID 9045618.
"EEA1 links PI(3)K function to Rab5 regulation of endosome fusion". Nature 394 (6692): 494–8. Jul 1998. doi:10.1038/28879. PMID 9697774. Bibcode: 1998Natur.394..494S.
"Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex". Biochemistry 37 (36): 12559–68. Sep 1998. doi:10.1021/bi980881a. PMID 9730828.
"Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochemical and Biophysical Research Communications 258 (3): 657–62. May 1999. doi:10.1006/bbrc.1999.0651. PMID 10329441.
"Direct interaction of EEA1 with Rab5b". European Journal of Biochemistry 265 (1): 361–6. Oct 1999. doi:10.1046/j.1432-1327.1999.00743.x. PMID 10491193.
"General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications". Biochemistry 38 (36): 11711–21. Sep 1999. doi:10.1021/bi990200r. PMID 10512627.
"Rab37 is a novel mast cell specific GTPase localized to secretory granules". FEBS Letters 470 (1): 61–4. Mar 2000. doi:10.1016/S0014-5793(00)01288-6. PMID 10722846.
"A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion". The Journal of Biological Chemistry 275 (32): 24661–9. Aug 2000. doi:10.1074/jbc.M909600199. PMID 10818110.
"Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain". The Journal of Cell Biology 151 (3): 601–12. Oct 2000. doi:10.1083/jcb.151.3.601. PMID 11062261.
"DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. Nov 2000. doi:10.1101/gr.143000. PMID 11076863.
"The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5". Nature 408 (6810): 374–7. Nov 2000. doi:10.1038/35042605. PMID 11099046. Bibcode: 2000Natur.408..374L.
"Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation". Journal of Neurobiology 49 (1): 62–78. Oct 2001. doi:10.1002/neu.1066. PMID 11536198.
"Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusion". The Journal of Biological Chemistry 277 (1): 679–85. Jan 2002. doi:10.1074/jbc.M109022200. PMID 11682489.