Biology:RASA4
From HandWiki
 Generic protein structure example |
Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.[1][2]
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates as GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.[2]
References
- ↑ "CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway". Curr Biol 11 (12): 981–6. Jul 2001. doi:10.1016/S0960-9822(01)00261-5. PMID 11448776.
- ↑ 2.0 2.1 "Entrez Gene: RASA4 RAS p21 protein activator 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10156.
Further reading
- "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. 1998. doi:10.1093/dnares/5.1.31. PMID 9628581.
- "Distinct phosphoinositide binding specificity of the GAP1 family proteins: characterization of the pleckstrin homology domains of MRASAL and KIAA0538.". Biochem. Biophys. Res. Commun. 288 (1): 87–90. 2001. doi:10.1006/bbrc.2001.5740. PMID 11594756.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. 2003. doi:10.1038/nature01782. PMID 12853948. Bibcode: 2003Natur.424..157H.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+.". J. Cell Biol. 170 (2): 183–90. 2005. doi:10.1083/jcb.200504167. PMID 16009725.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
External links
- RASA4 human gene location in the UCSC Genome Browser.
- RASA4 human gene details in the UCSC Genome Browser.
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