Biology:RIPK4
From HandWiki
Short description: Protein-coding gene in humans
 Generic protein structure example |
Receptor-interacting serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the RIPK4 gene.[1][2]
The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation.[2]
Interactions
RIPK4 has been shown to interact with PRKCB1.[3]
References
- ↑ "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. June 2000. doi:10.1038/35012518. PMID 10830953. Bibcode: 2000Natur.405..311H.
- ↑ 2.0 2.1 "Entrez Gene: RIPK4 receptor-interacting serine-threonine kinase 4". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=54101.
- ↑ Chen, L; Haider K; Ponda M; Cariappa A; Rowitch D; Pillai S (June 2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem. 276 (24): 21737–44. doi:10.1074/jbc.M008069200. ISSN 0021-9258. PMID 11278382.
Further reading
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "DIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysis". J. Biol. Chem. 275 (46): 36350–7. 2000. doi:10.1074/jbc.M004771200. PMID 10948194.
- "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem. 276 (24): 21737–44. 2001. doi:10.1074/jbc.M008069200. PMID 11278382.
- "RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-κB and is processed during apoptosis". EMBO Rep. 3 (12): 1201–8. 2003. doi:10.1093/embo-reports/kvf236. PMID 12446564.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner". J. Biol. Chem. 278 (24): 21526–33. 2003. doi:10.1074/jbc.M301575200. PMID 12676934.
- "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4. 2003. PMID 12747765.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Regulation of NF-kappaB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair". J. Invest. Dermatol. 127 (3): 538–44. 2007. doi:10.1038/sj.jid.5700588. PMID 17039240.
External links
- RIPK4 human gene location in the UCSC Genome Browser.
- RIPK4 human gene details in the UCSC Genome Browser.
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