Biology:RNF123

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

E3 ubiquitin-protein ligase RNF123 is an enzyme that in humans is encoded by the RNF123 gene.

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1 (Chaturvedi et al, 2012, PMID: 23077635).

See also

• RING finger domain

Further reading

• "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863. 
• "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. 2001. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336. 
• "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. 2004. doi:10.1073/pnas.0404089101. PMID 15498874. Bibcode: 2004PNAS..10115724W. 
• "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.". Nat. Cell Biol. 6 (12): 1229–35. 2005. doi:10.1038/ncb1194. PMID 15531880. 
• "Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase.". J. Biol. Chem. 280 (18): 17694–700. 2005. doi:10.1074/jbc.M500866200. PMID 15746103. 
• "Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle.". Mol. Cell. Biol. 25 (21): 9292–303. 2005. doi:10.1128/MCB.25.21.9292-9303.2005. PMID 16227581. 
• "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. 2006. doi:10.1093/nar/gkj139. PMID 16381901. 
• "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931. 

External links

• RNF123+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)