Biology:RNF4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

RING finger protein 4 is a protein that in humans is encoded by the RNF4 gene.

The protein encoded by this gene contains a RING finger domain and acts as a transcription factor. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ1 is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis.

Interactions

RNF4 has been shown to interact with TCF20, PATZ1 and Androgen receptor.

See also

• RING finger domain

Further reading

• "Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription". Molecular and Cellular Biology 18 (9): 5128–39. Sep 1998. doi:10.1128/mcb.18.9.5128. PMID 9710597. 
• "The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3". DNA Research 5 (3): 177–86. Jun 1998. doi:10.1093/dnares/5.3.177. PMID 9734812. 
• "Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms". The Journal of Biological Chemistry 275 (1): 571–9. Jan 2000. doi:10.1074/jbc.275.1.571. PMID 10617653. 
• "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor". The Journal of Biological Chemistry 275 (11): 7894–901. Mar 2000. doi:10.1074/jbc.275.11.7894. PMID 10713105. 
• "Rnf4, a RING protein expressed in the developing nervous and reproductive systems, interacts with Gscl, a gene within the DiGeorge critical region". Developmental Dynamics 218 (1): 102–11. May 2000. doi:10.1002/(SICI)1097-0177(200005)218:1<102::AID-DVDY9>3.0.CO;2-A. PMID 10822263. 
• "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". The Journal of Biological Chemistry 275 (34): 26144–9. Aug 2000. doi:10.1074/jbc.M003405200. PMID 10849425. 
• "The RING finger protein SNURF is a bifunctional protein possessing DNA binding activity". The Journal of Biological Chemistry 276 (26): 23653–60. Jun 2001. doi:10.1074/jbc.M009891200. PMID 11319220. 
• "Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein". The Journal of Biological Chemistry 277 (4): 2485–97. Jan 2002. doi:10.1074/jbc.M109021200. PMID 11696545. 
• "PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription". The Journal of Biological Chemistry 277 (5): 3280–5. Feb 2002. doi:10.1074/jbc.M109491200. PMID 11719514. 
• "Expression of the nuclear RING finger protein SNURF/RNF4 during rat testis development suggests a role in spermatid maturation". Mechanisms of Development 118 (1–2): 247–53. Oct 2002. doi:10.1016/S0925-4773(02)00261-7. PMID 12351196. 
• "Translational regulation of a novel testis-specific RNF4 transcript". Molecular Reproduction and Development 66 (1): 1–7. Sep 2003. doi:10.1002/mrd.10322. PMID 12874792. 
• "The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor". The Journal of Biological Chemistry 278 (40): 38780–5. Oct 2003. doi:10.1074/jbc.M306259200. PMID 12885770. 
• "Negative modulation of androgen receptor transcriptional activity by Daxx". Molecular and Cellular Biology 24 (24): 10529–41. Dec 2004. doi:10.1128/MCB.24.24.10529-10541.2004. PMID 15572661. 

External links

• RNF4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)