Biology:RNF5

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

E3 ubiquitin-protein ligase RNF5 is an enzyme that in humans is encoded by the RNF5 gene.

Function

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.

Further reading

• "Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci". Nucleic Acids Research 18 (24): 7251–7. December 1990. doi:10.1093/nar/18.24.7251. PMID 2259622. 
• "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. September 1996. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2". Journal of Cellular Biochemistry 79 (2): 213–24. August 2000. doi:10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G. PMID 10967549. 
• "Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase". Journal of Cell Science 114 (Pt 10): 1949–57. May 2001. doi:10.1242/jcs.114.10.1949. PMID 11329381. 
• "NG2 immunoreactivity on human brain endothelial cells". Acta Neuropathologica 102 (4): 313–20. October 2001. doi:10.1007/s004010000350. PMID 11603805. 
• "RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization". Molecular and Cellular Biology 23 (15): 5331–45. August 2003. doi:10.1128/MCB.23.15.5331-5345.2003. PMID 12861019. 
• "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Research 13 (12): 2621–36. December 2003. doi:10.1101/gr.1736803. PMID 14656967. 
• "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. January 2004. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. 
• "G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling". The Journal of Biological Chemistry 279 (51): 53196–204. December 2004. doi:10.1074/jbc.M410196200. PMID 15485865. 
• "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. March 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B. 
• "Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1". The Journal of Biological Chemistry 280 (46): 38682–8. November 2005. doi:10.1074/jbc.M506309200. PMID 16176924. 
• "Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator". Cell 126 (3): 571–82. August 2006. doi:10.1016/j.cell.2006.06.041. PMID 16901789. 
• "Increased expression of the E3 ubiquitin ligase RNF5 is associated with decreased survival in breast cancer". Cancer Research 67 (17): 8172–9. September 2007. doi:10.1158/0008-5472.CAN-07-0045. PMID 17804730. 
• "Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis". Cell Reports 24 (12): 3296–3311.e6. September 2018. doi:10.1016/j.celrep.2018.08.057. PMID 30232010. 

External links

• RNF5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)