Biology:rs7341475
From HandWiki
| SNP: rs7341475 | |
|---|---|
| Gene | RELN |
| Chromosome | 7 |
| Region | Intron 4 |
| External databases | |
| Ensembl | Human SNPView |
| dbSNP | 7341475 |
| HapMap | 7341475 |
| SNPedia | 7341475 |
| SzGene | Meta-analysis Overview |
In genetics, rs7341475 is a single nucleotide polymorphism (SNP) in the RELN gene that codes the reelin protein. The gene RELN is mapped to human chromosome 7 (7q22.1). The SNP rs7341475 is located in the fourth intron of RELN. The gene RELN has many more SNPs among its 65 exons and 64 introns, — even in intron 4 there are tens of SNPs.[1]
The SNP has been investigated for a possible link to schizophrenia. A 2008 genome-wide association study pointed to that a variant of the SNP could elevate the risk for schizophrenia among women.[2] A 2015 publication reported a meta-analysis across five studies concluding a slight effect of the SNP.[3]
References
- ↑ "SNP linked to Gene RELN". NCBI. https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?showRare=on&chooseRs=all&go=Go&locusId=5649. Retrieved 2008-09-09.
- ↑ Sagiv Shifman, Martina Johannesson, Michal Bronstein, Sam X. Chen, David A. Collier, Nicholas J. Craddock, Kenneth S. Kendler, Tao Li, Michael O'Donovan, F. Anthony O'Neill, Michael J. Owen, Dermot Walsh, Daniel R. Weinberger, Cuie Sun, Jonathan Flint & Ariel Darvasi (February 2008). "Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women". PLOS Genetics 4 (2): e28. doi:10.1371/journal.pgen.0040028. PMID 18282107. News:
- Eric Metcalf (2008-02-19). "Genetic Variant Found for Women's Schizophrenia". MentalHelp.net. Archived from the original on 2011-07-16. https://web.archive.org/web/20110716061326/http://www.mentalhelp.net/poc/view_doc.php?type=news&id=108022&cn=7. Retrieved 2008-09-09.
- "Gene variant linked to female schizophrenia". PsychiatryMatters.md. 2008-02-25. Archived from the original on 2013-02-19. https://archive.today/20130219030028/http://www.psychiatrymatters.md/headlines/fullpage.asp?C=45637397004821296296&xml=/headlines/2008/02_february/week_08/gene_variant_linked_to_female_schizophrenia.xml. Retrieved 2008-09-09.
- ↑ , Wikidata Q40444084
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