Biology:RyeE RNA
From HandWiki
| CyaR/Rye RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of CyaR_RyeE | |
| Identifiers | |
| Symbol | CyaR_RyeE |
| Alt. Symbols | RyeE |
| Rfam | RF00112 |
| Other data | |
| RNA type | Gene; sRNA |
| Domain(s) | Bacteria |
| SO | 0000655 |
| PDB structures | PDBe |
The CyaR RNA (formerly known as RyeE RNA) non-coding RNA was identified in a large scale screen of Escherichia coli and was called candidate 14.[1] The exact 5′ and 3′ ends of this RNA are uncertain. This gene lies between yegQ and orgK in E. coli. This small RNA was shown to be bound by the Hfq protein. This RNA has been renamed as CyaR for (cyclic AMP-activated RNA). It has been shown that the CyaR RNA acts as a repressor of the porin OmpX.[2] It has also been shown that cyaR expression is tightly controlled by the cyclic AMP receptor protein, CRP.[2]
A comparative genomics approach was able to detect and verify the additional targets ptsI, sdhA and yobF.[3]
See also
References
- ↑ Wassarman, KM; Repoila F; Rosenow C; Storz G; Gottesman S (2001). "Identification of novel small RNAs using comparative genomics and microarrays". Genes Dev 15 (13): 1637–1651. doi:10.1101/gad.901001. PMID 11445539.
- ↑ 2.0 2.1 "Systematic deletion of Salmonella small RNA genes identifies CyaR, a conserved CRP-dependent riboregulator of OmpX synthesis". Mol. Microbiol. 68 (4): 890–906. May 2008. doi:10.1111/j.1365-2958.2008.06189.x. PMID 18399940.
- ↑ "Comparative genomics boosts target prediction for bacterial small RNAs.". Proc Natl Acad Sci U S A 110 (37): E3487–E3496. 2013. doi:10.1073/pnas.1303248110. PMID 23980183. Bibcode: 2013PNAS..110E3487W.
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