Biology:SAT2
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 Generic protein structure example |
Diamine acetyltransferase 2 is an enzyme that in humans is encoded by the SAT2 gene.[1][2][3]
SAT2 maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate.[4]
References
- ↑ "Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism". Biochem J 384 (Pt 1): 139–48. Nov 2004. doi:10.1042/BJ20040790. PMID 15283699.
- ↑ "Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha". J Biol Chem 282 (32): 23572–80. Aug 2007. doi:10.1074/jbc.M703504200. PMID 17558023.
- ↑ "Entrez Gene: SAT2 spermidine/spermine N1-acetyltransferase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=112483.
- ↑ "System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate.". Cereb Cortex 19 (5): 1092–106. May 2009. doi:10.1093/cercor/bhn151. PMID 18832333.
Further reading
- "Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.". J. Biol. Chem. 282 (46): 33358–66. 2008. doi:10.1074/jbc.M705627200. PMID 17875644.
- "Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR.". Mol. Cell. Biochem. 298 (1–2): 59–68. 2007. doi:10.1007/s11010-006-9350-0. PMID 17119850.
- "Crystal structure of Homo sapiens thialysine Nepsilon-acetyltransferase (HsSSAT2) in complex with acetyl coenzyme A". Proteins 64 (1): 288–93. 2006. doi:10.1002/prot.20967. PMID 16596569.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase". Biochem. J. 373 (Pt 3): 661–7. 2003. doi:10.1042/BJ20030734. PMID 12803540.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
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