Biology:SH2D3C
 Generic protein structure example |
SH2 domain containing 3C, also known as SH2D3C, is a protein that in humans is encoded by the SH2D3C gene.[1]
Function
Sh2d3c is a gene on human chromosome 9 that encodes an SH2 domain containing protein known as NSP3. The mouse homologue is found on chromosome 2. The NSP (Novel SH2-containing Protein) family of proteins contains three members, NSP1, NSP2, and NSP3 (this protein), all of which have a similar architecture, with an N-terminal SH2 domain, a proline serine rich region, which contains consensus sequences for MAP kinase substrates, and a conserved C-terminus, which binds to the Cas family of adapter proteins, and also shows homology to GEF domains.
NSP3 was originally identified by three independent groups of researchers.[2][3][4] The mouse homologue of NSP3 has been shown to have two distinct isoforms, generated by alternative splicing, that are expressed in different tissues. The shorter isoform, known as Chat (Cas/Hef1 associated signal transducer) is expressed in brain, lung, heart, kidney, muscle, liver, and intestine, while the larger isoform, known as Chat-H (the "H" is for Hematopoietic), is expressed in spleen, thymus, and lymph nodes.[4] The two isoforms differ only in their N-terminus, which has been shown by one group to be important for membrane localization.[5]
Through its interaction with Hef1, Chat-H, has been shown to be an important regulator of lymphocyte adhesion, acting upstream of Rap1 in the integrin activation pathway.[5]
References
- ↑ "Entrez Gene: SH2D3C SH2 domain containing 3C". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10044.
- ↑ "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway". The Journal of Biological Chemistry 274 (15): 10047–52. April 1999. doi:10.1074/jbc.274.15.10047. PMID 10187783.
- ↑ "A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A". The Journal of Biological Chemistry 274 (45): 31941–6. November 1999. doi:10.1074/jbc.274.45.31941. PMID 10542222.
- ↑ 4.0 4.1 "Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways". The Journal of Biological Chemistry 275 (9): 6404–10. March 2000. doi:10.1074/jbc.275.9.6404. PMID 10692442.
- ↑ 5.0 5.1 "The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell trafficking". Immunity 25 (6): 907–18. December 2006. doi:10.1016/j.immuni.2006.09.014. PMID 17174122.
Further reading
- "AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology". Journal of Cellular Physiology 212 (3): 655–65. September 2007. doi:10.1002/jcp.21059. PMID 17427198.
- "Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling". Gene 391 (1–2): 161–70. April 2007. doi:10.1016/j.gene.2006.12.016. PMID 17270363.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases". The Journal of Biological Chemistry 279 (40): 41892–902. October 2004. doi:10.1074/jbc.M402929200. PMID 15272013.
- "A novel hematopoietic adaptor protein, Chat-H, positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells". The Journal of Biological Chemistry 278 (8): 6012–7. February 2003. doi:10.1074/jbc.M207942200. PMID 12486027.
- "Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways". The Journal of Biological Chemistry 275 (9): 6404–10. March 2000. doi:10.1074/jbc.275.9.6404. PMID 10692442.
- "A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A". The Journal of Biological Chemistry 274 (45): 31941–6. November 1999. doi:10.1074/jbc.274.45.31941. PMID 10542222.
- "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway". The Journal of Biological Chemistry 274 (15): 10047–52. April 1999. doi:10.1074/jbc.274.15.10047. PMID 10187783.
- "The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell trafficking". Immunity 25 (6): 907–18. December 2006. doi:10.1016/j.immuni.2006.09.014. PMID 17174122.
External links
- SH2D3C human gene location in the UCSC Genome Browser.
- SH2D3C human gene details in the UCSC Genome Browser.
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