Biology:SH2D3C

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SH2 domain containing 3C, also known as SH2D3C, is a protein that in humans is encoded by the SH2D3C gene.[1]

Function

Sh2d3c is a gene on human chromosome 9 that encodes an SH2 domain containing protein known as NSP3. The mouse homologue is found on chromosome 2. The NSP (Novel SH2-containing Protein) family of proteins contains three members, NSP1, NSP2, and NSP3 (this protein), all of which have a similar architecture, with an N-terminal SH2 domain, a proline serine rich region, which contains consensus sequences for MAP kinase substrates, and a conserved C-terminus, which binds to the Cas family of adapter proteins, and also shows homology to GEF domains.

NSP3 was originally identified by three independent groups of researchers.[2][3][4] The mouse homologue of NSP3 has been shown to have two distinct isoforms, generated by alternative splicing, that are expressed in different tissues. The shorter isoform, known as Chat (Cas/Hef1 associated signal transducer) is expressed in brain, lung, heart, kidney, muscle, liver, and intestine, while the larger isoform, known as Chat-H (the "H" is for Hematopoietic), is expressed in spleen, thymus, and lymph nodes.[4] The two isoforms differ only in their N-terminus, which has been shown by one group to be important for membrane localization.[5]

Through its interaction with Hef1, Chat-H, has been shown to be an important regulator of lymphocyte adhesion, acting upstream of Rap1 in the integrin activation pathway.[5]

References

  1. "Entrez Gene: SH2D3C SH2 domain containing 3C". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10044. 
  2. "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway". The Journal of Biological Chemistry 274 (15): 10047–52. April 1999. doi:10.1074/jbc.274.15.10047. PMID 10187783. 
  3. "A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A". The Journal of Biological Chemistry 274 (45): 31941–6. November 1999. doi:10.1074/jbc.274.45.31941. PMID 10542222. 
  4. 4.0 4.1 "Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways". The Journal of Biological Chemistry 275 (9): 6404–10. March 2000. doi:10.1074/jbc.275.9.6404. PMID 10692442. 
  5. 5.0 5.1 "The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell trafficking". Immunity 25 (6): 907–18. December 2006. doi:10.1016/j.immuni.2006.09.014. PMID 17174122. 

Further reading

External links