Biology:SRARP
 Generic protein structure example |
Steroid Receptor Associated and Regulated Protein (SRARP) in humans is a protein encoded by a gene of the same name with two exons that is located on chromosome 1p36.13.[1][2] SRARP contains 169 amino acids and has a molecular weight of 17,657 Da.[3]
Expression and function in breast cancer
SRARP is co-expressed with the estrogen receptor (ER) and androgen receptor (AR) in breast cancer.[4][5] In the ER-positive breast cancer cells, SRARP is involved in the transcriptional activities of ER and has shown an interaction with ER using the transient transfection of cells with SRARP and ER constructs.[6][7] In addition, in AR+ breast cancer cells, SRARP interacts with the endogenous AR protein and acts as a transcriptional corepressor of AR.[5] Furthermore, the activation of either AR or ER negatively regulates SRARP expression in breast cancer cells.[5][6]
Tumor suppressor function in malignancies
SRARP and HSPB7[8] are gene pairs that are positioned 5 kb apart on chromosome 1p36.13.[9] It is notable that the loss of chromosome 1p36.1 is common in malignancies, occurring in 34% of tumors[10][11] SRARP and HSPB7 are broadly inactivated in malignancies by epigenetic silencing, copy-number loss, and less frequently by somatic mutations.[9] In addition, overexpression of SRARP or HSPB7 leads to tumor suppressor effects in cancer cell lines.[9] Another similar molecular feature between SRARP and HSPB7 is the fact that both of these proteins interact with the 14-3-3 protein.[5][9] Furthermore, SRARP is a potential cancer biomarker and SRARP inactivation predicts poor clinical outcome in malignancies and adjacent normal tissues using the analysis of large genomic datasets[9]
| Approved Symbol | SRARP |
|---|---|
| Approved Name | Steroid Receptor Associated and Regulated Protein |
| HGNC ID | HGNC:28339 |
| Previous Symbol | C1orf64 |
| Alias Symbols | MGC24047, ERRF |
| Chromosome location | 1p36.13 |
| Ensembl | ENSG00000183888 |
| UniProt | Q8NEQ6 |
| NCBI Gene | 149563 |
| RefSeq | NM_178840 |
| UCSC | uc001axn.4 |
| Protein Sequence | SRARP Protein Sequence (Ensembl) |
| Wikidata | Q21105563 |
| PubMed | SRARP PubMed References |
References
- ↑ "SRARP". https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28339.
- ↑ "SRARP steroid receptor associated and regulated protein [ Homo sapiens (human) "]. https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=DetailsSearch&Term=149563.
- ↑ "Steroid receptor-associated and regulated protein". https://www.uniprot.org/uniprot/Q8NEQ6#sequences.
- ↑ "Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells". The American Journal of Pathology 180 (3): 1189–1201. March 2012. doi:10.1016/j.ajpath.2011.11.025. PMID 22341523.
- ↑ 5.0 5.1 5.2 5.3 "C1orf64 is a novel androgen receptor target gene and coregulator that interacts with 14-3-3 protein in breast cancer". Oncotarget 8 (34): 57907–57933. August 2017. doi:10.18632/oncotarget.17826. PMID 28915724.
- ↑ 6.0 6.1 "Estrogen-estrogen receptor signaling suppresses the transcription of ERRF in breast cancer cells". Journal of Genetics and Genomics = Yi Chuan Xue Bao 43 (9): 565–567. September 2016. doi:10.1016/j.jgg.2016.06.003. PMID 27599921.
- ↑ "ERRF is essential for Estrogen-Estrogen Receptor alpha signaling pathway in ER positive breast cancer cells". Biochemical and Biophysical Research Communications 474 (2): 400–405. May 2016. doi:10.1016/j.bbrc.2016.04.132. PMID 27125460.
- ↑ "Symbol report for HSPB7". HUGO Gene Nomenclature Committee (HGNC). https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/5249.
- ↑ 9.0 9.1 9.2 9.3 9.4 "SRARP and HSPB7 are epigenetically regulated gene pairs that function as tumor suppressors and predict clinical outcome in malignancies". Molecular Oncology 12 (5): 724–755. May 2018. doi:10.1002/1878-0261.12195. PMID 29577611.
- ↑ "1p36 tumor suppression--a matter of dosage?". Cancer Research 72 (23): 6079–88. December 2012. doi:10.1158/0008-5472.CAN-12-2230. PMID 23172308.
- ↑ "DNA copy number losses in human neoplasms". The American Journal of Pathology 155 (3): 683–94. September 1999. doi:10.1016/S0002-9440(10)65166-8. PMID 10487825.
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