Biology:SUI1 protein domain
| SUI1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 NMR solution structure of E. coli yciH gene. | |||||||||
| Identifiers | |||||||||
| Symbol | SUI1 | ||||||||
| Pfam | PF01253 | ||||||||
| InterPro | IPR001950 | ||||||||
| PROSITE | PDOC00862 | ||||||||
| SCOP2 | 2if1 / SCOPe / SUPFAM | ||||||||
| |||||||||
In molecular biology, the protein domain SUI1 is a translation initiation factor often found in the fungus, Saccharomyces cerevisiae (Baker's yeast) but it is also found in other eukaryotes and prokaryotes as well as archaea.
Function
SUI1 is a translation initiation factor that directs the ribosome to the translation start site, helped by eIF2 and the initiator Met-tRNAiMet.[1] SUI1 ensures that translation initiation commences from the correct start codon (usually AUG), by stabilizing the pre-initiation complex around the start codon. SUI1 promotes a high initiation fidelity for the AUG codon, discriminating against non-AUG codons.[2] .
Structure
The primary structure of the SUI1 protein is made up of 108 amino acids. The protein domain has a structure made of a seven-bladed beta-propeller and it also contains a C-terminal alpha helix.[3] Homologuess of SUI1 have been found [4] in mammals, insects and plants. SUI1 is also evolutionary related to hypothetical proteins from Escherichia coli (yciH), Haemophilus influenzae (HI1225) and Methanococcus vannielii.[3]
References
- ↑ "The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon". Molecular and Cellular Biology 12 (1): 248–60. January 1992. PMID 1729602.
- ↑ "Functional elements in initiation factors 1, 1A, and 2β discriminate against poor AUG context and non-AUG start codons". Molecular and Cellular Biology 31 (23): 4814–31. December 2011. doi:10.1128/MCB.05819-11. PMID 21930786.
- ↑ 3.0 3.1 "Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assembly". Nucleic Acids Research 40 (5): 2294–311. March 2012. doi:10.1093/nar/gkr765. PMID 22090426.
- ↑ "Expressed sequence tags identify a human isolog of the suil translation initiation factor". Biochemical and Biophysical Research Communications 198 (1): 288–91. January 1994. doi:10.1006/bbrc.1994.1040. PMID 7904817.
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