Biology:Serine 2-dehydrogenase

From HandWiki
Short description: Enzyme
serine 2-dehydrogenase
Identifiers
EC number1.4.1.7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a serine 2-dehydrogenase (EC 1.4.1.7) is an enzyme that catalyzes the chemical reaction

L-serine + H2O + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] 3-hydroxypyruvate + NH3 + NADH + H+

The 3 substrates of this enzyme are L-serine, H2O, and NAD+, whereas its 4 products are 3-hydroxypyruvate, NH3, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-serine:NAD+ 2-oxidoreductase (deaminating). Other names in common use include L-serine:NAD+ oxidoreductase (deaminating), and serine dehydrogenase.

References

  • "[The enzyme catalyzing the reductive amination of oxypyruvate]". Izv. Akad. Nauk. SSSR. Biol. 2: 295–300. 1966. PMID 5972761.