Biology:Small nucleolar RNA SNORD110

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Small Nucleolar RNA SNORD110
RF00610.jpg
Predicted secondary structure and sequence conservation of SNORD110
Identifiers
SymbolSNORD110
RfamRF00610
Other data
RNA typeGene; snRNA; snoRNA; C/D-box
Domain(s)Eukaryota
GO0006396 0005730
SO0000593
PDB structuresPDBe

In molecular biology, Small Nucleolar RNA SNORD110 (also known as HBII-55) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

HBII-55 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2′-O-methylation of substrate RNAs.[1] HBII-55 is predicted to guide the 2′O-ribose methylation of 18S ribosomal RNA (rRNA) at residue U1288.[2]

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