Biology:Small nucleolar RNA SNORD93
| Small Nucleolar RNA SNORD93 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORD93 | |
| Identifiers | |
| Symbol | SNORD93 |
| Rfam | RF00606 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; C/D-box |
| Domain(s) | Eukaryota |
| GO | 0006396 0005730 |
| SO | 0000593 |
| PDB structures | PDBe |
In molecular biology, Small Nucleolar RNA SNORD93 (also known as HBII-336) is a non-coding RNA (ncRNA) molecule that functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the Eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and is also often referred to as a guide RNA.
SNORD93 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] This snoRNA is the human orthologue of mouse snoRNA MBII-336.[2] SNORD93 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue A576.[3] Additionally, SNORD93 can be processed into a smaller, microRNA-like fragment (termed snoRNA-derived RNA(sdRNA)) that contributes to the malignant phenotype of breast cancer.[4] The processed piece (sdRNA-93) has been shown to target Pipox, a sarcosine metabolism-related protein whose expression significantly correlates with distinct molecular subtypes of breast cancer.
References
- ↑ "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology 22 (19): 6663–8. October 2002. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
- ↑ "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal 20 (11): 2943–53. June 2001. doi:10.1093/emboj/20.11.2943. PMID 11387227.
- ↑ "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Database issue): D158-62. January 2006. doi:10.1093/nar/gkj002. PMID 16381836.
- ↑ "Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion". npj Breast Cancer 3: 25. 2017. doi:10.1038/s41523-017-0032-8. PMID 28702505.
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