Biology:Small nucleolar RNA SNORD99
| Small Nucleolar RNA SNORD99 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORD99 | |
| Identifiers | |
| Symbol | SNORD99 |
| Rfam | RF00608 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; C/D-box |
| Domain(s) | Eukaryota |
| GO | 0006396 0005730 |
| SO | 0000593 |
| PDB structures | PDBe |
In molecular biology, Small Nucleolar RNA SNORD99 (also known as HBII-420) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
SNORD99 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] SNORD99 is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA at residue A2774.[2] In the human genome this snoRNA shares the same host gene with the three H/ACA box snoRNAs ACA16, ACA44 and ACA61.[2]
References
- ↑ "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology 22 (19): 6663–8. October 2002. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
- ↑ 2.0 2.1 "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Database issue): D158-62. January 2006. doi:10.1093/nar/gkj002. PMID 16381836.
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