Biology:YWHAG
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
14-3-3 protein gamma is a protein that in humans is encoded by the YWHAG gene.[1][2]
This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.[3]
Interactions
YWHAG has been shown to interact with C-Raf,[2][4][5] EPB41L3,[4][6] KIF1C[7] and Stratifin.[8]
References
- ↑ "Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23". Genomics 60 (2): 241–3. September 1999. doi:10.1006/geno.1999.5887. PMID 10486217.
- ↑ 2.0 2.1 "14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells". DNA and Cell Biology 18 (7): 555–64. July 1999. doi:10.1089/104454999315105. PMID 10433554.
- ↑ "Entrez Gene: YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7532.
- ↑ 4.0 4.1 "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- ↑ "14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation". The Biochemical Journal 345 Pt 2 (2): 297–306. January 2000. doi:10.1042/0264-6021:3450297. PMID 10620507.
- ↑ "The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins". The Biochemical Journal 365 (Pt 3): 783–9. August 2002. doi:10.1042/BJ20020060. PMID 11996670.
- ↑ "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". The Journal of Biological Chemistry 274 (47): 33654–60. November 1999. doi:10.1074/jbc.274.47.33654. PMID 10559254.
- ↑ "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics 4 (6): 785–95. June 2005. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Further reading
- "14-3-3: modulators of signaling proteins?". Science 266 (5182): 56–7. October 1994. doi:10.1126/science.7939645. PMID 7939645. https://zenodo.org/record/1231237.
- "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA and Cell Biology 23 (4): 193–205. April 2004. doi:10.1089/104454904773819789. PMID 15142377. https://zenodo.org/record/1235217.
- "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Annals of the New York Academy of Sciences 1024: 153–67. June 2004. doi:10.1196/annals.1321.013. PMID 15265780. Bibcode: 2004NYASA1024..153K. https://zenodo.org/record/1235880.
- "Characterization of 14-3-3 proteins in adrenal chromaffin cells and demonstration of isoform-specific phospholipid binding". The Biochemical Journal 301 ( Pt 1) (1): 305–10. July 1994. doi:10.1042/bj3010305. PMID 8037685.
- "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". The Journal of Biological Chemistry 271 (33): 20029–34. August 1996. doi:10.1074/jbc.271.33.20029. PMID 8702721.
- "Expression of 14-3-3 gamma in injured arteries and growth factor- and cytokine-stimulated human vascular smooth muscle cells". Cell Growth & Differentiation 7 (11): 1453–60. November 1996. PMID 8930394.
- "Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins". The EMBO Journal 17 (7): 1892–906. April 1998. doi:10.1093/emboj/17.7.1892. PMID 9524113.
- "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". The Journal of Biological Chemistry 274 (47): 33654–60. November 1999. doi:10.1074/jbc.274.47.33654. PMID 10559254.
- "Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family". European Journal of Biochemistry 267 (9): 2680–7. May 2000. doi:10.1046/j.1432-1327.2000.01285.x. PMID 10785390.
- "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155". The Biochemical Journal 349 (Pt 2): 547–57. July 2000. doi:10.1042/0264-6021:3490547. PMID 10880354.
- "Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting". The Biochemical Journal 354 (Pt 3): 605–12. March 2001. doi:10.1042/0264-6021:3540605. PMID 11237865.
- "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology 287 (2): 359–70. September 2001. doi:10.1006/viro.2001.1007. PMID 11531413.
- "Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21)". Electrophoresis 23 (1): 152–7. January 2002. doi:10.1002/1522-2683(200201)23:1<152::AID-ELPS152>3.0.CO;2-T. PMID 11824616.
- "Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms". The Journal of Biological Chemistry 277 (20): 18029–36. May 2002. doi:10.1074/jbc.M110465200. PMID 11886850.
- "The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins". The Biochemical Journal 365 (Pt 3): 783–9. August 2002. doi:10.1042/BJ20020060. PMID 11996670.
- "Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells". Journal of Cell Science 115 (Pt 17): 3479–90. September 2002. doi:10.1242/jcs.115.17.3479. PMID 12154078. http://repository.ust.hk/ir/bitstream/1783.1-1608/1/3479.pdf.
- "Identification and characterization of the interaction between tuberin and 14-3-3zeta". The Journal of Biological Chemistry 277 (42): 39417–24. October 2002. doi:10.1074/jbc.M204802200. PMID 12176984.
External links
- Overview of all the structural information available in the PDB for UniProt: P61981 (14-3-3 protein gamma (YWHAG)) at the PDBe-KB.
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