Biology:TAF5L
 Generic protein structure example |
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L is an enzyme that in humans is encoded by the TAF5L gene.[1][2][3]
Function
The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[3]
Interactions
TAF5L has been shown to interact with TAF9[4] and Transcription initiation protein SPT3 homolog.[4]
References
- ↑ "Histone-like TAFs within the PCAF histone acetylase complex". Cell 94 (1): 35–44. Aug 1998. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425.
- ↑ "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast 18 (1): 69–80. Jan 2001. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.
- ↑ 3.0 3.1 "Entrez Gene: TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27097.
- ↑ 4.0 4.1 "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Mol. Cell. Biol. 21 (20): 6782–95. Oct 2001. doi:10.1128/MCB.21.20.6782-6795.2001. PMID 11564863.
Further reading
- "The TAFs in the HAT". Cell 94 (1): 1–4. 1998. doi:10.1016/S0092-8674(00)81213-1. PMID 9674419.
- "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction". J. Biol. Chem. 274 (26): 18285–9. 1999. doi:10.1074/jbc.274.26.18285. PMID 10373431.
- "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". EMBO J. 20 (12): 3187–96. 2001. doi:10.1093/emboj/20.12.3187. PMID 11406595.
- "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Mol. Cell. Biol. 21 (20): 6782–95. 2001. doi:10.1128/MCB.21.20.6782-6795.2001. PMID 11564863.
- "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis". Proteomics 3 (2): 217–23. 2003. doi:10.1002/pmic.200390030. PMID 12601814.
- "Six lysine residues on c-Myc are direct substrates for acetylation by p300". Biochem. Biophys. Res. Commun. 336 (1): 274–80. 2005. doi:10.1016/j.bbrc.2005.08.075. PMID 16126174.
- "The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients". Autoimmunity 38 (4): 283–93. 2005. doi:10.1080/08916930500128594. PMID 16206511.
- "Muscle cell survival mediated by the transcriptional coactivators p300 and PCAF displays different requirements for acetyltransferase activity". Am. J. Physiol., Cell Physiol. 291 (4): C699-709. 2006. doi:10.1152/ajpcell.00056.2006. PMID 16672693.
- "PCAF modulates PTEN activity". J. Biol. Chem. 281 (36): 26562–8. 2006. doi:10.1074/jbc.M605391200. PMID 16829519.
- "Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression". EMBO J. 26 (12): 2880–9. 2007. doi:10.1038/sj.emboj.7601715. PMID 17476304.
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