Biology:Transcription initiation protein SPT3 homolog
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Transcription initiation protein SPT3 homolog is a protein that in humans is encoded by the SUPT3H gene.[1][2][3]
Interactions
Transcription initiation protein SPT3 homolog has been shown to interact with GCN5L2,[4][5] TAF6L,[5] TADA3L,[5] TAF5L,[5] SF3B3,[5] SUPT7L,[5] Myc,[6] TAF9,[5] Transformation/transcription domain-associated protein,[5] TAF12,[5] TAF10,[4][5] TAF4[4] and DDB1.[5]
Model organisms
Model organisms have been used in the study of SUPT3H function. A conditional knockout mouse line called Supt3tm1a(EUCOMM)Hmgu was generated at the Wellcome Trust Sanger Institute.[7] Male and female animals underwent a standardized phenotypic screen[8] to determine the effects of deletion.[9][10][11][12] Additional screens performed: - In-depth immunological phenotyping[13]
| Characteristic | Phenotype |
|---|---|
| All data available at.[8][13] | |
| Peripheral blood leukocytes 6 Weeks | Normal |
| Insulin | Normal |
| Haematology 6 Weeks | Normal |
| Homozygous viability at P14 | Abnormal |
| Recessive lethal study | Abnormal |
| Body weight | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology 16 Weeks | Normal |
| Peripheral blood leukocytes 16 Weeks | Normal |
| Heart weight | Normal |
| Salmonella infection | Normal |
| Cytotoxic T Cell Function | Normal |
| Spleen Immunophenotyping | Normal |
| Mesenteric Lymph Node Immunophenotyping | Normal |
| Bone Marrow Immunophenotyping | Normal |
| Epidermal Immune Composition | Normal |
| Trichuris Challenge | Normal |
References
- ↑ "Histone-like TAFs within the PCAF histone acetylase complex". Cell 94 (1): 35–44. Jul 1998. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425.
- ↑ "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID". The Journal of Biological Chemistry 273 (37): 23781–5. Sep 1998. doi:10.1074/jbc.273.37.23781. PMID 9726987.
- ↑ "Entrez Gene: SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8464.
- ↑ 4.0 4.1 4.2 "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". The EMBO Journal 20 (12): 3187–96. Jun 2001. doi:10.1093/emboj/20.12.3187. PMID 11406595.
- ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology 21 (20): 6782–95. Oct 2001. doi:10.1128/MCB.21.20.6782-6795.2001. PMID 11564863.
- ↑ "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry 278 (22): 20405–12. May 2003. doi:10.1074/jbc.M211795200. PMID 12660246.
- ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ 8.0 8.1 "International Mouse Phenotyping Consortium". http://www.mousephenotype.org/data/search?q=Supt3#fq=*:*&facet=gene.
- ↑ "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. Jun 2011. doi:10.1038/nature10163. PMID 21677750.
- ↑ "Mouse library set to be knockout". Nature 474 (7351): 262–3. Jun 2011. doi:10.1038/474262a. PMID 21677718.
- ↑ "A mouse for all reasons". Cell 128 (1): 9–13. Jan 2007. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. Jul 2013. doi:10.1016/j.cell.2013.06.022. PMID 23870131.
- ↑ 13.0 13.1 "Infection and Immunity Immunophenotyping (3i) Consortium". http://www.immunophenotyping.org/data/search?keys=Supt3&field_gene_construct_tid=All.
Further reading
- "Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor spt3 (SUPT3H)". Genomics 53 (1): 90–6. Oct 1998. doi:10.1006/geno.1998.5500. PMID 9787080.
- "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily". Molecular Cell 2 (6): 869–75. Dec 1998. doi:10.1016/S1097-2765(00)80301-9. PMID 9885574.
- "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction". The Journal of Biological Chemistry 274 (26): 18285–9. Jun 1999. doi:10.1074/jbc.274.26.18285. PMID 10373431.
- "Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes". Molecular and Cellular Biology 21 (6): 1973–85. Mar 2001. doi:10.1128/MCB.21.6.1973-1985.2001. PMID 11238933.
- "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". The EMBO Journal 20 (12): 3187–96. Jun 2001. doi:10.1093/emboj/20.12.3187. PMID 11406595.
- "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology 21 (20): 6782–95. Oct 2001. doi:10.1128/MCB.21.20.6782-6795.2001. PMID 11564863.
- "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis". Proteomics 3 (2): 217–23. Feb 2003. doi:10.1002/pmic.200390030. PMID 12601814.
- "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry 278 (22): 20405–12. May 2003. doi:10.1074/jbc.M211795200. PMID 12660246.
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