Biology:TRNA (cytosine38-C5)-methyltransferase
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Short description: Class of enzymes
| TRNA (cytosine38-C5)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.204 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
TRNA (cytosine38-C5)-methyltransferase (EC 2.1.1.204, hDNMT2 (gene), DNMT2 (gene), TRDMT1 (gene)) is an enzyme with the systematic name S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction:
- S-adenosyl-L-methionine + cytosine38 in tRNA [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA
The eukaryotic enzyme catalyses methylation of cytosine38 in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC).
See also
- TRDMT1
References
- ↑ "Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2". Science 311 (5759): 395–8. January 2006. doi:10.1126/science.1120976. PMID 16424344.
- ↑ "Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism". RNA 14 (8): 1663–70. August 2008. doi:10.1261/rna.970408. PMID 18567810.
- ↑ "RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage". Genes & Development 24 (15): 1590–5. August 2010. doi:10.1101/gad.586710. PMID 20679393.
External links
- TRNA+(cytosine38-C5)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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