Biology:TRNA (guanine10-N2)-dimethyltransferase
From HandWiki
| TRNA (guanine10-N2)-dimethyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.213 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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TRNA (guanine10-N2)-dimethyltransferase (EC 2.1.1.213, PAB1283, N(2),N(2)-dimethylguanosine tRNA methyltransferase, Trm-G10, PabTrm-G10, PabTrm-m2 2G10 enzyme) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine10-N2)-dimethyltransferase.[1] This enzyme catalyses the following chemical reaction
- 2 S-adenosyl-L-methionine + guanine10 in tRNA [math]\displaystyle{ \rightleftharpoons }[/math] 2 S-adenosyl-L-homocysteine + N2-dimethylguanine10 in tRNA (overall reaction)
- (1a) S-adenosyl-L-methionine + guanine10 in tRNA [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA
- (1b) S-adenosyl-L-methionine + N2-methylguanine10 in tRNA [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + N2-dimethylguanine10 in tRNA
References
- ↑ "N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota". The Journal of Biological Chemistry 279 (35): 37142–52. August 2004. doi:10.1074/jbc.m403845200. PMID 15210688.
External links
- TRNA+(guanine10-N2)-dimethyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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