Biology:TUC338
| TUC338 | |
|---|---|
| Identifiers | |
| Symbol | TUC338 |
| Other data | |
| RNA type | Gene |
| Domain(s) | Vertebrata |
| Locus | Chr. 12 q |
| PDB structures | PDBe |
TUC338 (transcribed ultra-conserved region 338) is an ultra-conserved element which is transcribed to give a non-coding RNA.[1][2] The TUC338 gene was first identified as uc.338, along with 480 other ultra-conserved elements in the human genome.[3] Expression of this RNA gene has been found to dramatically increase in hepatocellular carcinoma (HCC) cells.[4]
The TUC338 RNA gene is 590 base-pairs long, and partially overlaps the gene encoding Poly(rC)-binding protein 2 (PCBP2), a protein involved in mRNA processing.[5] Despite this overlap, PCBP2 and TUC388 were found to be independently expressed.[4]
TUC338 is predicted to function in cell growth, possibly at the interface between G1 phase and S phase, and could potentially present a therapeutic target to treat HCC cells.[4] Experimental evidence shows knocking out TUC338 using siRNA reduced the growth rate of both mouse and human HCC cells.[4]
References
- ↑ "Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas". Cancer Cell 12 (3): 215–229. September 2007. doi:10.1016/j.ccr.2007.07.027. PMID 17785203.
- ↑ "A distal enhancer and an ultraconserved exon are derived from a novel retroposon". Nature 441 (7089): 87–90. May 2006. doi:10.1038/nature04696. PMID 16625209. Bibcode: 2006Natur.441...87B.
- ↑ "Ultraconserved elements in the human genome". Science 304 (5675): 1321–1325. May 2004. doi:10.1126/science.1098119. PMID 15131266. Bibcode: 2004Sci...304.1321B.
- ↑ 4.0 4.1 4.2 4.3 "Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America 108 (2): 786–791. January 2011. doi:10.1073/pnas.1011098108. PMID 21187392. Bibcode: 2011PNAS..108..786B.
- ↑ "Identification of the poly(C) binding protein in the complex associated with the 3′ untranslated region of erythropoietin messenger RNA". Blood 93 (6): 2111–2120. March 1999. doi:10.1182/blood.V93.6.2111.406k24_2111_2120. PMID 10068686.
External links
Further reading
- "Molecular and functional genetics of hepatocellular carcinoma". Frontiers in Bioscience 2 (1): 117–134. 2010-01-01. doi:10.2741/s51. PMID 20036934.
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