Biology:KIF1C
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Kinesin-like protein KIF1C is a protein that in humans is encoded by the KIF1C gene.[1][2] Kif1C is a fast, plus-end directed microtubule motor.[3] It takes processive 8nm steps along microtubules and can generate forces of up to 5 pN.[4] Kif1C transports α5β1-integrins in human cells.[5] Kif1C has been shown to be non-essential in mouse with other proteins able to perform the same function.[6] However, mutations in KIF1C lead to spastic paraplegia and cerebellar dysfunction in humans.[7][8][9][10] These mutations usually result in a total loss of the protein or (partial) loss of function, such as significant lower force output.[11]
Interactions
KIF1C has been shown to interact with PTPN21[1] and YWHAG.[12] KIF1C is a dimeric molecule that is held in an autoinhibited state by interaction of its stalk with the microtubule binding interface of the motor domain. Upon binding of PTPN21 or the cargo adapter HOOK3 to the KIF1C stalk, the motor domain is released, engages with microtubules and commences transport.[13]
References
- ↑ 1.0 1.1 "Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum". The Journal of Biological Chemistry 273 (32): 20267–75. August 1998. doi:10.1074/jbc.273.32.20267. PMID 9685376.
- ↑ "Entrez Gene: KIF1C kinesin family member 1C". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10749.
- ↑ "KIF1D is a fast non-processive kinesin that demonstrates novel K-loop-dependent mechanochemistry". The EMBO Journal 20 (18): 5101–13. September 2001. doi:10.1093/emboj/20.18.5101. PMID 11566875.
- ↑ Siddiqui, Nida; Roth, Daniel; Toleikis, Algirdas; Zwetsloot, Alexander J.; Cross, Robert A.; Straube, Anne (September 2022). "Force generation of KIF1C is impaired by pathogenic mutations". Current Biology 32 (17): 3862–3870.e6. doi:10.1016/j.cub.2022.07.029. PMID 35961316.
- ↑ "Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions". Developmental Cell 23 (6): 1153–66. December 2012. doi:10.1016/j.devcel.2012.11.005. PMID 23237952.
- ↑ "Molecular motor KIF1C is not essential for mouse survival and motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport". Molecular and Cellular Biology 22 (3): 866–73. February 2002. doi:10.1128/MCB.22.3.866-873.2002. PMID 11784862.
- ↑ "Motor protein mutations cause a new form of hereditary spastic paraplegia". Neurology 82 (22): 2007–16. June 2014. doi:10.1212/WNL.0000000000000479. PMID 24808017.
- ↑ "KIF1C mutations in two families with hereditary spastic paraparesis and cerebellar dysfunction". Journal of Medical Genetics 51 (2): 137–42. February 2014. doi:10.1136/jmedgenet-2013-102012. PMID 24319291.
- ↑ "Clinical phenotype of hereditary spastic paraplegia due to KIF1C gene mutations across life span". Brain & Development 40 (6): 458–464. June 2018. doi:10.1016/j.braindev.2018.02.013. PMID 29544888.
- ↑ "KIF1C Variants Are Associated with Hypomyelination, Ataxia, Tremor, and Dystonia in Fraternal Twins". Tremor and Other Hyperkinetic Movements 9. 2019. doi:10.7916/tohm.v0.641. PMID 31413903.
- ↑ Siddiqui, Nida; Roth, Daniel; Toleikis, Algirdas; Zwetsloot, Alexander J.; Cross, Robert A.; Straube, Anne (September 2022). "Force generation of KIF1C is impaired by pathogenic mutations". Current Biology 32 (17): 3862–3870.e6. doi:10.1016/j.cub.2022.07.029. PMID 35961316.
- ↑ "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". The Journal of Biological Chemistry 274 (47): 33654–60. November 1999. doi:10.1074/jbc.274.47.33654. PMID 10559254.
- ↑ "PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport". Nature Communications 10 (1): 2693. June 2019. doi:10.1038/s41467-019-10644-9. PMID 31217419. Bibcode: 2019NatCo..10.2693S.
Further reading
- "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research 5 (3): 169–76. June 1998. doi:10.1093/dnares/5.3.169. PMID 9734811.
- "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". The Journal of Biological Chemistry 274 (47): 33654–60. November 1999. doi:10.1074/jbc.274.47.33654. PMID 10559254.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "The kinesin KIF1C and microtubule plus ends regulate podosome dynamics in macrophages". Molecular Biology of the Cell 17 (6): 2811–23. June 2006. doi:10.1091/mbc.E05-11-1010. PMID 16554367.
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology 24 (10): 1285–92. October 2006. doi:10.1038/nbt1240. PMID 16964243.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. November 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
External links
- Overview of all the structural information available in the PDB for UniProt: O43896 (Kinesin-like protein KIF1C) at the PDBe-KB.
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