Biology:ZMYND8

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Protein kinase C-binding protein 1 is an enzyme that in humans is encoded by the ZMYND8 gene.[1]

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene.[1]

Model organisms

Model organisms have been used in the study of ZMYND8 function. A conditional knockout mouse line, called Zmynd8tm1a(EUCOMM)Wtsi[4][5] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[6][7][8]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[2][9] Twenty one tests were carried out on mutant mice and two significant abnormalities were observed.[2] Few homozygous mutant embryos were identified during gestation and none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.[2]

References

  1. 1.0 1.1 "Entrez Gene: ZMYND8 zinc finger, MYND-type containing 8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23613. 
  2. 2.0 2.1 2.2 2.3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  3. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  4. "International Knockout Mouse Consortium". http://www.knockoutmouse.org/martsearch/search?query=Zmynd8. 
  5. "Mouse Genome Informatics". http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4433147. 
  6. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M. et al. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMID 21677750. 
  7. Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  8. "A Mouse for All Reasons". Cell 128 (1): 9–13. 2007. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  9. "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. 2011. doi:10.1186/gb-2011-12-6-224. PMID 21722353. 

Further reading