Chemistry:3-HO-PCE
3-Hydroxyeticyclidine (3-HO-PCE) is a novel dissociative drug of the arylcyclohexylamine class, related to phencyclidine. It was first identified as a novel psychoactive substance in Sweden in 2017, and has subsequently been sold online as a research chemical.[1] The toxicity and long-term safety profile of 3-HO-PCE is unknown as it has a very limited history of use.
Use and effects
3-HO-PCE is reported to have dissociative, hallucinogenic, and addictive effects.[2] The dissociative effects have specifically been described as "lying halfway between 3-MeO-PCP and 3-MeO-PCE."[3]
Early discussions of 3-HO-PCE online revolved around whether it possesses an appreciable affinity for the μ-opioid receptor given its structural relationship to 3-HO-PCP, which has been shown to display a high affinity for the receptor in animal models.[2][4][5] Users have confirmed that it does possess some opioid-like effects.[2] It is described as being weaker and more functional at low doses compared to other drugs in its class such as O-PCE and 3-MeO-PCE.[2] Doses range anywhere from 5 to 30 mg.[2][5]
Toxicity
A study examining structure-activity relationships of phencyclidine analogs using computer models found 3-HO-PCE to likely have toxic effects, including a 67% probability of cardiovascular toxicity.[6]
Chemistry
3-HO-PCE is composed of cyclohexane, a six-member saturated ring, bonded to two additional groups at R1. One of these groups is an ethyl chain bonded at its nitrogen group. The other ring is an aromatic phenyl ring, substituted at R3 with a hydroxy group.[5]
3-HO-PCE is an analog of PCE (also called eticyclidine) and structurally homologous to 3-MeO-PCE.[5]
Society and culture
Legal status
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3-HO-PCE is illegal in Germany under the NpSG act, which serves as a blanket ban for various research chemicals.
It is also a controlled substance in the United Kingdom, Turkey, and Switzerland.
See also
References
- ↑ "EMCDDA–Europol 2017 Annual Report on the implementation of Council Decision 2005/387/JHA". European Monitoring Center for Drugs and Drug Addiction. 10 August 2018. https://www.euda.europa.eu/publications/implementation-reports/2017_en.
- ↑ 2.0 2.1 2.2 2.3 2.4 "The Big & Dandy 3-HO-PCE Thread". 4 January 2017. https://bluelight.org/vb/threads/812314-The-Big-amp-Dandy-3-HO-PCE-Thread.
- ↑ "Characterization of 3-Hydroxyeticyclidine (3-HO-PCE) Metabolism in Human Liver Microsomes and Biological Samples Using High-Resolution Mass Spectrometry". Metabolites 13 (3). 2023. doi:10.3390/metabo13030432.
- ↑ "Cheminform Abstract: Structure-Activity Relationship of SOME Phencyclidine Derivatives- In VIVO Studies in Mice". Chemischer Informationsdienst 9 (25). 20 June 1978. doi:10.1002/chin.197825192. ISSN 00092975.
- ↑ 5.0 5.1 5.2 5.3 Josikins (2017-02-24). "3-HO-PCE". PsychonautWiki. https://psychonautwiki.org/wiki/3-HO-PCE.
- ↑ "Qualitative and quantitative in silico toxicity profiling of "angel dust": phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE)". Archives of Toxicology 100 (3): 1049–1079. March 2026. doi:10.1007/s00204-025-04242-6. PMID 41361125.
External links
- 3-HO-PCE - Isomer Design
- 3-HO-PCE - PsychonautWiki
- [The Big & Dandy 3-HO-PCE Thread - Bluelight]
- 3-HO-PCE - TrippyWiki
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