Chemistry:4-Fluoroaniline
From HandWiki
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| Names | |
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| Other names
p-Fluoroaniline
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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| UNII | |
| UN number | 2941 |
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| Properties | |
| C6H6FN | |
| Molar mass | 111.119 g·mol−1 |
| Appearance | colorless liquid |
| Density | 1.1725 g/cm3 |
| Melting point | −1.9 °C (28.6 °F; 271.2 K) |
| Boiling point | 188 °C (370 °F; 461 K) |
| Hazards | |
| GHS pictograms |    
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| GHS Signal word | Danger |
| H302, H312, H314, H315, H317, H319, H332, H372, H373, H410, H411 | |
| P260, P261, P264, P264+265Script error: No such module "Preview warning".Category:GHS errors, P270, P271, P272, P273, P280, P301+317Script error: No such module "Preview warning".Category:GHS errors, P301+330+331, P302+352, P302+361+354Script error: No such module "Preview warning".Category:GHS errors, P304+340, P305+351+338, P305+354+338Script error: No such module "Preview warning".Category:GHS errors, P316Script error: No such module "Preview warning".Category:GHS errors, P317Script error: No such module "Preview warning".Category:GHS errors, P319Script error: No such module "Preview warning".Category:GHS errors, P321, P330, P332+317Script error: No such module "Preview warning".Category:GHS errors, P333+313, P337+317Script error: No such module "Preview warning".Category:GHS errors, P362+364Script error: No such module "Preview warning".Category:GHS errors | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Tracking categories (test):
4-Fluoroaniline is an organofluorine compound with the formula FC
6H
4NH
2. A colorless liquid, it is one of three isomers of fluoroaniline. It is used as a precursor to various potential and real applications.
4-Fluoroaniline can be prepared by the hydrogenation of 4-nitrofluorobenzene.[2]
It is a common building block in medicinal chemistry and related fields.[3] For example, it is a precursor to the fungicide fluoroimide. It has also been evaluated for the production of ligands for homogeneous catalysis.[4]
References
- ↑ "4-Fluoroaniline" (in en). https://pubchem.ncbi.nlm.nih.gov/compound/9731#section=Safety-and-Hazards.
- ↑ Jagadeesh, Rajenahally V.; Surkus, Annette-Enrica; Junge, Henrik; Pohl, Marga-Martina; Radnik, Jörg; Rabeah, Jabor; Huan, Heming; Schünemann, Volker et al. (2013). "Nanoscale Fe2O3-Based Catalysts for Selective Hydrogenation of Nitroarenes to Anilines". Science 342 (6162): 1073–1076. doi:10.1126/science.1242005. PMID 24288327. Bibcode: 2013Sci...342.1073J.
- ↑ Wei, Jinbao; Chen, Jinghong; Ju, Peijun; Ma, Le; Chen, Li; Ma, Weidong; Zheng, Tao; Yang, Guangyi et al. (2019). "Synthesis and Biological Evaluation of 4β-N-Acetylamino Substituted Podophyllotoxin Derivatives as Novel Anticancer Agents". Frontiers in Chemistry 7: 253. doi:10.3389/fchem.2019.00253. PMID 31106192. Bibcode: 2019FrCh....7..253W.
- ↑ Mitani, Makoto; Mohri, Jun-Ichi; Yoshida, Yasunori; Saito, Junji; Ishii, Seiichi; Tsuru, Kazutaka; Matsui, Shigekazu; Furuyama, Rieko et al. (2002). "Living Polymerization of Ethylene Catalyzed by Titanium Complexes Having Fluorine-Containing Phenoxy−Imine Chelate Ligands". Journal of the American Chemical Society 124 (13): 3327–3336. doi:10.1021/ja0117581. PMID 11916417.
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