Chemistry:AC-90179
From HandWiki
Short description: Chemical compound
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| Formula | C23H30N2O2 |
| Molar mass | 366.505 g·mol−1 |
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AC-90179 is a piperidine derivative which acts as an inverse agonist at the 5-HT2A serotonin receptor and an antagonist at 5-HT2C. It was developed as a potential antipsychotic but was not pursued for medical applications due to poor oral bioavailability; however, it continues to be used as a tool compound in pharmacological research.[1][2]
See also
References
- ↑ "5-hydroxytryptamine2A receptor inverse agonists as antipsychotics". The Journal of Pharmacology and Experimental Therapeutics 299 (1): 268–76. October 2001. PMID 11561089.
- ↑ "Pharmacological characterization of AC-90179 [2-(4-methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride]: a selective serotonin 2A receptor inverse agonist". The Journal of Pharmacology and Experimental Therapeutics 310 (3): 943–51. September 2004. doi:10.1124/jpet.104.066688. PMID 15102927.
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