Chemistry:AGH-192

AGH-192
Identifiers
	IUPAC name 3-(3-ethylimidazol-4-yl)-4-fluoro-5-iodo-1H-indole;
PubChem CID	139488606;
Chemical and physical data
Formula	C13H11FIN3
Molar mass	355.155 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN1C=NC=C1C2=CNC3=C2C(=C(C=C3)I)F;
	InChI InChI=1S/C13H11FIN3/c1-2-18-7-16-6-11(18)8-5-17-10-4-3-9(15)13(14)12(8)10/h3-7,17H,2H2,1H3; Key:KBQLQDPQEMFGCB-UHFFFAOYSA-N;

Short description: Chemical compound

AGH-192 is a potent and selective, water soluble, orally bioavailable and brain penetrant full agonist at the 5HT₇ serotonin receptor, derived from the older drug AGH-107. In animal tests it showed activity indicative of potential application in the treatment of neuropathic pain.^[1]

References

↑ "Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers". European Journal of Medicinal Chemistry 170: 261–275. 2019. doi:10.1016/j.ejmech.2019.03.017. PMID 30904783.

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Original source: https://en.wikipedia.org/wiki/AGH-192. Read more

[1] "Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers". European Journal of Medicinal Chemistry 170: 261–275. 2019. doi:10.1016/j.ejmech.2019.03.017. PMID 30904783.

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Identifiers

IUPAC name 3-(3-ethylimidazol-4-yl)-4-fluoro-5-iodo-1H-indole
PubChem CID	139488606
Chemical and physical data
Formula	C₁₃H₁₁FIN₃
Molar mass	355.155 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCN1C=NC=C1C2=CNC3=C2C(=C(C=C3)I)F
InChI InChI=1S/C13H11FIN3/c1-2-18-7-16-6-11(18)8-5-17-10-4-3-9(15)13(14)12(8)10/h3-7,17H,2H2,1H3 Key:KBQLQDPQEMFGCB-UHFFFAOYSA-N

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