Chemistry:Anaritide
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Short description: Synthetic Peptide
![]() Tertiary structure of Anaritide | |
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Formula | C112H177N39O35S3 |
Molar mass | 2726.07 g·mol−1 |
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Anaritide (also known as human atrial natriuretic peptide [102-126])[1] is a synthetic analogue of atrial natriuretic peptide[2] (ANP).
Structure
Anartidine has the following primary structure:[3]
RSSCFGGRMDRIGAQSGLGCNSFRY
or
H-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH
This structure is identical to residues 102-126 of human preproANP.[1][4] In comparison, active human ANP comprises resides 99-126 of human preproANP.[5]
Medical uses
Anaritide has been investigated as a potential therapy for acute tubular necrosis but was shown not to improve the dialysis-free survival of these patients.[2] It also appears to exacerbate proteinuria and natriuresis in patients with nephrotic syndrome.[6]
References
- ↑ 1.0 1.1 "Bronchoprotective and bronchodilator activity of anaritide (human atrial natriuretic factor [102-126]) infusion in the anesthetized guinea pig". Pulmonary Pharmacology 1 (3): 119–123. 1988-07-22. doi:10.1016/S0952-0600(88)80009-7. PMID 2980981.
- ↑ 2.0 2.1 "Anaritide in acute tubular necrosis. Auriculin Anaritide Acute Renal Failure Study Group". The New England Journal of Medicine 336 (12): 828–834. March 1997. doi:10.1056/NEJM199703203361203. PMID 9062091.
- ↑ "Splenic artery aneurysm of the anomalous splenomesenteric trunk: successful treatment by transcatheter embolization using detachable coils". CardioVascular and Interventional Radiology 29 (3): 432–434. 2006. doi:10.1007/s00270-005-0036-x. PMID 16132382.
- ↑ "Amino acid sequence of atrial natriuretic peptides in human coronary sinus plasma". Biochemical and Biophysical Research Communications 146 (2): 832–839. July 1987. doi:10.1016/0006-291X(87)90606-1. PMID 2956952.
- ↑ "Atrial natriuretic factor and related peptide hormones". Annual Review of Biochemistry 60: 229–255. 1991. doi:10.1146/annurev.bi.60.070191.001305. PMID 1652921.
- ↑ "Effect of synthetic human atrial natriuretic peptide (102-126) in nephrotic syndrome". Kidney International 34 (5): 717–724. November 1988. doi:10.1038/ki.1988.238. PMID 2974095.
![]() | Original source: https://en.wikipedia.org/wiki/Anaritide.
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