Chemistry:Antiarin

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Antiarins
Alpha-antiarin.png
α-Antiarin
Beta-antiarin.png
β-Antiarin
Names
IUPAC names
α-Antiarin: (3S,5S,8R,9S,10S,12R,13S,14S,17R)-5,12,14-trihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-3-[(2R,3R,4R,5R,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde
β-Antiarin: (3S,5S,8R,9S,10S,12R,13S,14S,17R)-5,12,14-trihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
Properties
C29H42O11
Molar mass 566.644 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Antiarins are cardiac glycoside poisons produced by the upas tree (Antiaris toxicaria).[1] There are two closely related forms, α-antiarin and β-antiarin. The two share the same aglycone, antiarigenin, but differ in the sugar group that is attached to it.

α-Antiarin

α-Antiarin is a crystalline solid with a melting point of 242-242.5 °C.[2] The sugar portion of α-antiarin is antiarose (D-gulomethylose).[3]

In addition to being present in the sap of the upas tree, it is also found in the latex of Naucleopsis mello-barretoi.[4]

β-Antiarin

is a crystalline solid with a melting point of 233-240 °C.[5] The sugar portion of β-antiarin is L-rhamnose.[3]

The uses of β-antiarin range from medical use, such as hypertension treatment, to arrow poison application. It also proves to be more poisonous than curare, sporting a low -1">50 of 0.1 mg/kg in most mammals.[6]

Antiaris toxicaria in Jardin Botanique de Kandy

Symptoms of β-antiarin poisoning

Upon β-antiarin poisoning, when observed in animals such as frogs and small mammals, visible symptoms include muscle spasms — particularly of the head and neck — and excess defecation. Paralysis can also be presented before death. The primary physiological system affected is the cardiac muscle, though gastro-intestinal tissue has also been known to be severely affected by this type of poisoning. Convulsions and spasms are not immediate, especially when the chemical is too diluted in water. In animal tests, time of death resulted anywhere from 5–30 minutes after administration.[7] When used as an arrow poison, β-antiarin produces twitches in the target, which then become full convulsions, unconsciousness, and final death through cardiac arrest.[6]

Toxicity of β-antiarin

During tests performed on frogs and mammals, it was found that the minimum lethal dose for an amphibian was 1/300th mg. For a 300-400 g guinea pig, this lethal dose increased to 0.75 mg.[7] Lethal dose for felines is 0.094 mg/kg, using intravenous injection.[8] Meanwhile, 1 mg will kill a dog.[6]

Physiological systems affected/medical properties

β-Antiarin is administered to the body through injection. Once inside the body, the chemical will affect muscular and cardiac tissues.[7] A heart attack occurs because β-antiarin affects Na+K+-ATPase cardiac-muscle membrane activity.[6]

Sodium calcium pump

However, the very effect that allows β-antiarin to be a poison also gives it medicinal properties. It limits the sodium ion (Na+) concentration by blocking the Na+ pump, which then promotes calcium ions (Ca2+) to increase in concentration in the extracellular cardiac muscle domain, therein permitting the heart to contract.[9] The mechanism through which sodium and calcium ions are exchanged, known as the sodium-calcium exchanger, allows for the exchange of ions to occur at a rate of 3:1 respectively. The cardiac cell exhibits a positive potential during ventricular systole, becomes depolarized, and permits calcium ions to rush in by the sodium-calcium exchanger. From here, the contraction occurs when the calcium ions leave and the cell re-polarizes.[10] If the dosage of cardiac glycoside (i.e. β-antiarin) doubles, then the substance becomes a poison.[9]

Cultural references

Four Dayak tribesmen in a warfare ritual

The earliest known use of antiarins as an arrow poison was with the Li people in China, circa 581. Other cultures, such as the peoples of the Dayak tribe, Berusu, Punan, and Basap in Borneo, southeast Asia, have also used the sap of the upas tree for poisoned darts.[6] Indigenous people would collect the sap in a bamboo fixture (or upas leaf if amount needed is small), then place over an open flame for a week. Extreme care was taken to make sure the sap does not boil over; to make sure the poison was not lost, small taste tests would be performed as the sap continues to be dehydrated. A sweet taste would indicate that the sugar group in β-antiarin had cleaved, thus ruining the potency of the poison and freeing the sugar into the sap.[11] Final poisonous sap would be a dark black, metallic color and have a bitter taste; this is usually achieved at the end of seven days. The sap can then be used to coat the arrow tips, and its potency continues to be effective for years as long as care is taken to make sure the tip is not re-exposed to heat. Even hardened, stored poison could still be lethal when reconstructed with the root sap of Derris elliptica, strychnos, or snake poison. The arrows could be used for hunting as well as defense; if the tissue surrounding the arrowhead was cut off and the meat cooked, the poison's sugar group would break off, rendering it harmless.[6]

References

  1. ↑ Dolder, F.; Tamm, Ch.; Reichstein, T. (1955). "Glycosides and aglycons. CL. The glycosides of Antiaris toxicaria". Helvetica Chimica Acta 38: 1364–96. doi:10.1002/hlca.19550380608. 
  2. ↑ "α-Antiarin". CAS Common Chemistry. Chemical Abstracts Service. https://commonchemistry.cas.org/detail?cas_rn=23605-05-2. 
  3. ↑ 3.0 3.1 The Merck Index (11th ed.). p. 117. 731. α-Antiarin. 
  4. ↑ Bisset, Norman G.; Hylands, Peter J. (1977). "Cardiotonic glycosides from the latex of naucleopsis mello-barretoi, a dart-poison plant from North-West Brazil". Economic Botany 31 (3): 307–311. doi:10.1007/BF02866881. 
  5. ↑ Martin, R. P. (1959). "Beitrag zur Konstitution des Antiarigenins. Glykoside und Aglykone, 199. Mitteilung" (in de). Helvetica Chimica Acta 42 (3): 696–712. doi:10.1002/hlca.19590420309. 
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Zahorka, Herwig. "Blowpipe dart poison in Borneo and the secret of its production: the latex of Antiaris toxicaria; the poison-making procedure; the heat-sensitive main toxic chemical compound, and the lethal effect of the poison.". http://www.thefreelibrary.com/Blowpipe+dart+poison+in+Borneo+and+the+secret+of+its+production%3a+the...-a0166350047. 
  7. ↑ 7.0 7.1 7.2 Seligmann, C. G. (1903). "On the Physiological Action of the Kenyah Dart Poison Ipoh, and its Active Principle Antiarin". Journal of Physiology 29 (1): 39–57. doi:10.1113/jphysiol.1903.sp000945. PMID 16992656. 
  8. ↑ US National Library of Medicine Toxnet--Toxicology Data Network. "Substance Name: beta-Antiarin". National Institutes of Health. https://chem.nlm.nih.gov/chemidplus/rn/639-13-4. [|permanent dead link|dead link}}]
  9. ↑ 9.0 9.1 Manunta, Paolo; Ferrandi, Mara (2006). "Cardiac Glycosides and Cardiomyopathy". Hypertension (American Heart Association) 47 (3): 343–344. doi:10.1161/01.HYP.0000202641.29167.c0. PMID 16461849. http://hyper.ahajournals.org/content/47/3/343.full. 
  10. ↑ E. Klabunde, PhD, Richard. "Sodium-Calcium Exchange in Cardiac Cells". Jimp Studio. http://cvphysiology.com/Cardiac%20Function/CF023.htm. 
  11. ↑ Fieser, Louis; Fieser, Mary (1959). Steroids. Reinhold Publishing Corporation. pp. 765–767. https://archive.org/details/steroids00fies. 



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