Chemistry:BMS-466442

From HandWiki

BMS-466442 is an experimental drug that acts as a selective inhibitor of the amino acid transporter alanine serine cysteine transporter-1 (ASC-1). It indirectly increases activation of the NMDA receptor by boosting intracellular levels of the endogenous ligands glycine and D-serine. It was developed as a potential treatment for schizophrenia.[1][2][3]

References

  1. ↑ "In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10)". Journal of Neurochemistry 129 (2): 275–283. April 2014. doi:10.1111/jnc.12618. PMID 24266811. 
  2. ↑ "Inhibition of the Alanine-Serine-Cysteine-1 Transporter by BMS-466442". ACS Chemical Neuroscience 10 (5): 2510–2517. May 2019. doi:10.1021/acschemneuro.9b00019. PMID 30821959. 
  3. ↑ "ASC-1 transporter-dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation". FEBS Letters 595 (16): 2085–2098. August 2021. doi:10.1002/1873-3468.14155. PMID 34197627. 



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