Chemistry:Bis-tris methane

Bis-tris methane

Names
Preferred IUPAC name 2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
Other names Bis-(2-hydroxy-ethyl)-amino-tris(hydroxymethyl)-methane 2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-1,3-propanediol 2,2-Bis(hydroxymethyl)-2,2,2-nitrilotriethanol
Identifiers
CAS Number	6976-37-0 Y
3D model (JSmol)	Interactive image
Beilstein Reference	2205275
ChEBI	CHEBI:41250 Y
ChemSpider	73505 Y
EC Number	230-237-7
Gmelin Reference	4519
MeSH	Bistris
PubChem CID	81462
UNII	Q1XC3631CP Y
InChI InChI=1S/C8H19NO5/c10-3-1-9(2-4-11)8(5-12,6-13)7-14/h10-14H,1-7H2 Y Key: OWMVSZAMULFTJU-UHFFFAOYSA-N Y
SMILES OCCN(CCO)C(CO)(CO)CO
Properties
Chemical formula	C8H19NO5
Molar mass	209.242 g·mol−1
Appearance	White crystals
Odor	Odourless
Melting point	102 to 103 °C (216 to 217 °F; 375 to 376 K)
Solubility in water	209.2 g L−1 (at 20 °C)
Acidity (pKa)	6.46
Basicity (pKb)	7.54
UV-vis (λmax)	280 nm
Absorbance	0.15
Hazards
GHS pictograms
GHS Signal word	WARNING
GHS hazard statements	H315, H319, H335
GHS precautionary statements	P261, P305+351+338
NFPA 704 (fire diamond)	0 2 0
Related compounds
Related alkanols	N-Methylethanolamine Dimethylethanolamine Diethylethanolamine Diethanolamine N,N-Diisopropylaminoethanol Methyl diethanolamine Triethanolamine Meglumine
Related compounds	Diethylhydroxylamine
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Tracking categories (test):

• SizeSet

Bis-tris methane, also known as BIS-TRIS or BTM, is a buffering agent used in biochemistry. Bis-tris methane is an organic tertiary amine with labile protons having a pKa of 6.46 at 25 °C. It is an effective buffer between the pH 5.8 and 7.2. Bis-tris methane binds strongly to Cu and Pb ions as well as, weakly, to Mg, Ca, Mn, Co, Ni, Zn and Cd.

See also

• Bis-tris propane
• Tris
• Tricine