Chemistry:Carboxycyclophosphamide
From HandWiki
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| Names | |
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| Preferred IUPAC name
3-({Amino[bis(2-chloroethyl)amino]phosphoryl}oxy)propanoic acid | |
| Other names
Carboxyphosphamide
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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| UNII | |
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| Properties | |
| C7H15Cl2N2O4P | |
| Molar mass | 293.084762 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
Carboxycyclophosphamide is an inactive metabolite of the cytotoxic antineoplastic drug cyclophosphamide. In the metabolic pathway of cyclophosphamide inactivation it first metabolizes to 4-hydroxycyclophosphamide, then partially tautomerizes into aldophosphamide. Aldophosphamide then, in turn, is oxidized into carboxycyclophosphamide by the enzyme ALDH (aldehyde dehydrogenase).[1]
References
- ↑ Dockham, PA; Lee, MO; Sladek, NE (1992). "Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde". Biochem Pharmacol 43 (11): 2453–69. doi:10.1016/0006-2952(92)90326-e. PMID 1610409.
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