Chemistry:Cimlanod
From HandWiki
Short description: Chemical compound
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| Formula | C5H7NO4S |
| Molar mass | 177.17 g·mol−1 |
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Cimlanod (development codes CXL-1427 and BMS-986231) is an experimental drug for the treatment of acute decompensated heart failure. It was discovered by Cardioxyl Pharmaceuticals, which was acquired by Bristol-Myers Squibb. It is a precursor of nitroxyl.[1]
Cimlanod is a prodrug of CXL-1020.[2]
A preliminary study showed efficacy in patients with class III and IV heart failure.[3] A phase II clinical trial was completed in 2016.[4]
References
- ↑ "BMS 986231". AdisInsight. Springer Nature Switzerland AG. http://adisinsight.springer.com/drugs/800040055. Retrieved 2017-05-22. "Alternative Names: BMS-986231; CXL 1427; HNO Donor"
- ↑ "CXL 1020". AdisInsight. Springer Nature Switzerland AG. http://adisinsight.springer.com/drugs/800030450. Retrieved 2017-05-22.
- ↑ "Nitroxyl prodrug shows promise in acute heart failure". 22 May 2016. http://www.mdedge.com/ecardiologynews/article/109035/heart-failure/nitroxl-prodrug-shows-promise-acute-heart-failure.
- ↑ Clinical trial number NCT02157506 for "A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure" at ClinicalTrials.gov
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