Chemistry:Clofoctol
From HandWiki
Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria.[1] It has been marketed in France till 2005 under the trade name Octofene and in Italy as Gramplus.[citation needed]
It is only functional against Gram-positive bacteria.[2]
It penetrates into human lung tissue.[3]
A French company, Apteeus had been developing clofoctol as a potential therapy against SARS-CoV-2 in 2020-2021, but eventually the repurposing of the drug was abandoned, due to a lack of volunteers.[4][5][6][7][8][9] A mouse study showed repurposed drug clofoctol blocks SARS-CoV-2 replication.[10][11]
References
- ↑ "Gramplus" (in it). Studio Medico Torrino. July 25, 2007. http://www.torrinomedica.it/studio/schedefarmaci/GRAMPLUS.htm.
- ↑ "[Clofoctol binding by the bacteria (author's transl)]" (in fr). Journal de Pharmacologie 11 (4): 411–425. 1980. PMID 6782374.
- ↑ "A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay". Drugs Under Experimental and Clinical Research 14 (1): 39–43. 1988. PMID 3391105.
- ↑ "Pasteur Lille obtient 5 M€ de LVMH pour repositionner un ancien médicament, l'Octofene, sur le traitement du Covid" (in fr). AEF info. 2020-10-13. https://www.aefinfo.fr/depeche/637456-pasteur-lille-obtient-5-m-de-lvmh-pour-repositionner-un-ancien-medicament-l-octofene-sur-le-traitement-du-covid.
- ↑ "La piste clofoctol. Interview du Pr Xavier Nassif". Jim.fr. 2021-09-13. https://www.jim.fr/medecin/actualites/pro_societe/e-docs/la_piste_clofoctol._interview_du_pr_xavier_nassif_189116/document_actu_pro.phtml.
- ↑ "Hope for an Anti-COVID Drug" (in en). ARTE G.E.I.E.. 2021-05-21. https://www.arte.tv/en/videos/100942-000-A/arte-reportage/.
- ↑ "La molécule miracle !" (in fr). 2022-07-04. https://www.weo.fr/video/docu-la-molecule-miracle/.
- ↑ "French institute aims to start human trials of 'promising' Covid-19 drug this winter" (in en). 2020-10-01. https://www.france24.com/en/20201001-french-institute-aims-to-start-human-trials-of-promising-covid-19-drug-this-winter.
- ↑ "Covid-19: un reportage sur les chercheurs de l'institut Pasteur de Lille ce samedi sur Arte" (in fr). 2020-06-20. https://actu.fr/hauts-de-france/lille_59350/covid-19-un-reportage-sur-les-chercheurs-de-l-institut-pasteur-de-lille-ce-samedi-sur-arte_34408184.html.
- ↑ "Repurposed drug clofoctol blocks SARS-CoV-2 replication in mouse study" (in en). 2022-05-23. https://www.news-medical.net/news/20220523/Repurposed-drug-clofoctol-blocks-SARS-CoV-2-replication-in-mouse-study.aspx.
- ↑ "Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice". PLOS Pathogens 18 (5). May 2022. doi:10.1371/journal.ppat.1010498. PMID 35587469.
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