Chemistry:Clofoctol
From HandWiki
Short description: Chemical compound
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Rectal (suppository)[1] |
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| Bioavailability | 98%[1] |
| Metabolism | Hepatic glucuronidation[1] |
| Excretion | Biliary[1] |
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| Formula | C21H26Cl2O |
| Molar mass | 365.34 g·mol−1 |
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Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria.[1] It has been marketed in France till 2005 under the trade name Octofene and in Italy as Gramplus.[citation needed]
It is only functional against Gram-positive bacteria.[2]
It penetrates into human lung tissue.[3]
Apteeus is developing clofoctol as a potential therapy against SARS-CoV-2.[4][5]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 "Gramplus" (in it). Studio Medico Torrino. July 25, 2007. http://www.torrinomedica.it/studio/schedefarmaci/GRAMPLUS.htm.
- ↑ "[Clofoctol binding by the bacteria (author's transl)]" (in fr). J Pharmacol 11 (4): 411–25. 1980. PMID 6782374.
- ↑ "A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay". Drugs Exp Clin Res 14 (1): 39–43. 1988. PMID 3391105.
- ↑ "Pasteur Lille obtient 5 M€ de LVMH pour repositionner un ancien médicament, l'Octofene, sur le traitement du Covid" (in fr). AEF info. October 13, 2020. https://www.aefinfo.fr/depeche/637456-pasteur-lille-obtient-5-m-de-lvmh-pour-repositionner-un-ancien-medicament-l-octofene-sur-le-traitement-du-covid.
- ↑ "La piste clofoctol. Interview du Pr Xavier Nassif". Jim.fr. 13 September 2021. https://www.jim.fr/medecin/actualites/pro_societe/e-docs/la_piste_clofoctol._interview_du_pr_xavier_nassif_189116/document_actu_pro.phtml.
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