Chemistry:Cyclopregnol
From HandWiki
Short description: Chemical compound
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| Other names | Neurosterone; 6β-Hydroxy-3:5-cyclopregnan-20-one |
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| Formula | C21H32O2 |
| Molar mass | 316.485 g·mol−1 |
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Cyclopregnol (INN), also known as neurosterone, as well as 6β-hydroxy-3:5-cyclopregnan-20-one, is a synthetic pregnane steroid which was developed in the 1950s as a "psychotropic agent" for the treatment of mental disorders but was never marketed.[1][2][3][4] Although an initial small clinical study found effectiveness,[3] a subsequent, larger and more rigorous study found that cyclopregnol was no more effective than placebo and was clearly inferior to chlorpromazine.[4][5]
See also
References
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 646–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA646.
- ↑ "133. 6β-Hydroxy-3 : 5-cyclopregnan-20-one and some related compounds". J. Chem. Soc.: 665–668. 1957. doi:10.1039/JR9570000665. ISSN 0368-1769.
- ↑ 3.0 3.1 "6 beta-Hydroxy-3:5-cyclopregnan-20-one in mental states". The Journal of Mental Science 103 (433): 835–839. October 1957. doi:10.1192/bjp.103.433.835. PMID 13481595.
- ↑ 4.0 4.1 "Treatment of acute mental disorders with an adrenal steroid". The British Journal of Psychiatry 114 (512): 843–844. July 1968. doi:10.1192/bjp.114.512.843. PMID 4874165.
- ↑ "Antipyschotic and Anti-anxiety Agents". Annual Reports in Medicinal Chemistry. Academic Press. 1969. pp. 3–. ISBN 978-0-08-058348-8. https://books.google.com/books?id=rDUMWpvOgjkC&pg=PA3.
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