Chemistry:DMG-PEG 2000
From HandWiki
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| Names | |
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| IUPAC name
1,2-Dimyristoyl-sn-glycero-3-methoxypolyethylene glycol
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| Other names
PEG-DMG
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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| Properties | |
| C 122H 242O 50 | |
| Molar mass | 570.89[1] |
| Appearance | powder[1] |
| Hazards | |
| GHS pictograms |  [2]
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| GHS Signal word | Danger[2] |
| H315, H319[2] | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
DMG-PEG 2000 is a synthetic lipid formed by the PEGylation of myristoyl diglyceride. It is used to manufacture lipid nanoparticles that are used in mRNA vaccines,[3] and in particular forms part of the drug delivery system for the Moderna COVID-19 vaccine.[4]
Main applications
DMG-PEG 2000 has similar chemical properties to the phospholipids that make up the cell membrane. This enables lipid nanoparticles composed of it to easily merge with the cell membrane, delivering its contents. [1]
See also
- Moderna COVID-19 vaccine nanoparticle ingredients
- Distearoylphosphatidylcholine
- SM-102
- Cholesterol
References
- ↑ 1.0 1.1 1.2 "DMG-PEG 2000 powder". https://www.sigmaaldrich.com/AU/en/product/avanti/880151p.
- ↑ 2.0 2.1 2.2 "DMG-PEG(2000)". https://www.chemicalbook.com/ChemicalProductProperty_EN_CB39739399.htm.
- ↑ "Development of an Alcohol Dilution-Lyophilization Method for Preparing Lipid Nanoparticles Containing Encapsulated siRNA". Biological & Pharmaceutical Bulletin 41 (8): 1291–1294. 2018. doi:10.1248/bpb.b18-00208. PMID 30068880.
- ↑ "Moderna COVID-19 Vaccine Standing Orders for Administering Vaccine to Persons 18 Years of Age and Older". Centers for Disease Control and Prevention (CDC). https://www.cdc.gov/vaccines/covid-19/info-by-product/moderna/downloads/standing-orders.pdf.
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