Chemistry:Denifanstat
From HandWiki
Short description: Chemical compound
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| Other names | TVB-2640 |
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| Formula | C27H29N5O |
| Molar mass | 439.563 g·mol−1 |
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Denifanstat (TVB-2640) is a small-molecule drug and fatty acid synthase inhibitor. Developed by Sagimet Biosciences, it has been tested in various types of cancer[1][2][3][4] and for non-alcoholic steatohepatitis.[5]
References
- ↑ Falchook, Gerald; Infante, Jeffrey; Arkenau, Hendrik-Tobias; Patel, Manish R.; Dean, Emma; Borazanci, Erkut; Brenner, Andrew; Cook, Natalie et al. (April 2021). "First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors". eClinicalMedicine 34: 100797. doi:10.1016/j.eclinm.2021.100797. PMID 33870151.
- ↑ Konkel, Brandon; Michalek, Joel; Diaz Duque, Enrique; Liu, Qiangia; Caflisch, Laura; Madhu, Vinu; Brenner, Andrew (11 November 2019). "Actr-45. Fatty Acid Synthase Inhibitor TVB-2640 Increases Progression Free Survival in Recurrent GBM". Neuro-Oncology 21 (Supplement_6): vi23. doi:10.1093/neuonc/noz175.087.
- ↑ Dean, Emma Jane; Falchook, Gerald Steven; Patel, Manish R.; Brenner, Andrew Jacob; Infante, Jeffrey R.; Arkenau, Hendrik-Tobias; Borazanci, Erkut Hasan; Lopez, Juanita Suzanne et al. (20 May 2016). "Preliminary activity in the first in human study of the first-in-class fatty acid synthase (FASN) inhibitor, TVB-2640.". Journal of Clinical Oncology 34 (15_suppl): 2512. doi:10.1200/JCO.2016.34.15_suppl.2512.
- ↑ Kelly, William; Diaz Duque, Adolfo Enrique; Michalek, Joel; Konkel, Brandon; Caflisch, Laura; Chen, Yidong; Pathuri, Sarath Chand; Madhusudanannair-Kunnuparampil, Vinu et al. (5 July 2023). "Phase II Investigation of TVB-2640 (Denifanstat) with Bevacizumab in Patients with First Relapse High-Grade Astrocytoma". Clinical Cancer Research 29 (13): 2419–2425. doi:10.1158/1078-0432.CCR-22-2807. PMID 37093199.
- ↑ "CTG Labs - NCBI". https://clinicaltrials.gov/study/NCT04906421?start=2019-11-03_&aggFilters=funderType:industry,phase:2%203&limit=100&cond=NASH&rank=59.
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