Chemistry:Diphenylmethanol
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| Names | |
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| Preferred IUPAC name
Diphenylmethanol | |
| Other names
Benzhydrol
Diphenylcarbinol Hydroxydiphenylmethane | |
| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C13H12O | |
| Molar mass | 184.238 g·mol−1 |
| Appearance | White crystals |
| Density | 1.103 g/cm3 |
| Melting point | 69 °C (156 °F; 342 K) |
| Boiling point | 298 °C (568 °F; 571 K) |
| 0.5 g/L (20 °C) | |
| -119.1·10−6 cm3/mol | |
| Hazards[2] | |
| GHS pictograms | 
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| GHS Signal word | Warning |
| H315, H319, H335 | |
| P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405, P501 | |
| Related compounds | |
Related compounds
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Benzophenone |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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| Infobox references | |
Diphenylmethanol is the organic compound with the formula (C6H5)2CHOH. Also known as benzhydrol, it is a white solid and the parent member of a large class of diaryl alcohols.
Preparation
Diphenylmethanol may be prepared by a Grignard reaction between phenylmagnesium bromide and benzaldehyde[citation needed]. An alternative method involves reducing benzophenone with sodium borohydride or with zinc dust or with sodium amalgam and water.[3]
Uses and safety
It has uses in perfume and pharmaceutical manufacture. In perfumery it is used as a fixative. In pharmaceutical manufacture it is used in the synthesis of antihistamines / antiallergenic agents and antihypertensive agents . It is used in the synthesis of modafinil[4] and the benzhydryl group is present in the structure of many histamine H1 antagonists like diphenylhydramine. Benzhydrol is also used in the production of agrochemicals as well as other organic compounds and as a terminating group in polymerizations.
Diphenylmethanol is an irritant to the eyes, skin and respiratory system.
References
- ↑ MSDS[yes|permanent dead link|dead link}}]
- ↑ "Diphenylmethanol" (in en). https://pubchem.ncbi.nlm.nih.gov/compound/7037#section=Safety-and-Hazards.
- ↑ Wiselogle, F. Y.; Sonneborn, III, H. (1928). "Benzohydrol". Organic Syntheses 8: 23. doi:10.15227/orgsyn.008.0024.
- ↑ Rose, Sebastien & Dominique Klein, "Method for preparing methyl 2-diphenylmethylsulfinylacetate", EP patent 1583739, published 2005-10-12
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