Chemistry:FK962
From HandWiki
Short description: Somatostatin release enhancer
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| Formula | C14H17FN2O2 |
| Molar mass | 264.300 g·mol−1 |
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FK962 is a compound which acts as an enhancer of somatostatin release. It stimulates nerve growth and neurite elongation, and has been researched in animal models for potential applications in the treatment of conditions such as Alzheimer's disease and retinal neuropathy.[1][2][3][4]
See also
- Octreotide
- Pasireotide
- Sunifiram (structural similarity)
References
- ↑ "FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats". European Journal of Pharmacology 527 (1–3): 111–120. December 2005. doi:10.1016/j.ejphar.2005.10.022. PMID 16325809.
- ↑ "FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease". Pharmacology, Biochemistry, and Behavior 98 (1): 76–80. March 2011. doi:10.1016/j.pbb.2010.11.019. PMID 21130801.
- ↑ "FK962 promotes neurite elongation and regeneration of cultured rat trigeminal ganglion cells: possible involvement of GDNF". Investigative Ophthalmology & Visual Science 53 (9): 5312–5319. August 2012. doi:10.1167/iovs.11-8957. PMID 22714891.
- ↑ "FK962 induces neurite outgrowth in cultured monkey trigeminal ganglion cells". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie 255 (1): 107–112. January 2017. doi:10.1007/s00417-016-3525-5. PMID 27778122.
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