Chemistry:Ferroquine
From HandWiki
Short description: Chemical compound
 | |
| Identifiers | |
|---|---|
| |
| CAS Number | |
| PubChem CID | |
| Chemical and physical data | |
| Formula | C23H24ClFeN3 |
| Molar mass | 433.76 g·mol−1 |
| |
Ferroquine is a synthetic compound related to chloroquine which acts as an antimalarial, and shows good activity against chloroquine-resistant strains.[1] It contains an organometallic ferrocene ring which is unusual in pharmaceuticals,[2][3][4] and while it was first reported in 1997,[5] it has progressed slowly through clinical trials, with results from Phase II trials showing reasonable safety and efficacy, and further trials ongoing.[6][7]
References
- ↑ "In vitro antimalarial activity of a new organometallic analog, ferrocene-chloroquine". Antimicrobial Agents and Chemotherapy 42 (3): 540–544. March 1998. doi:10.1128/AAC.42.3.540. PMID 9517929.
- ↑ "Ferrocene conjugates of chloroquine and other antimalarials: the development of ferroquine, a new antimalarial". ChemMedChem 3 (3): 383–391. March 2008. doi:10.1002/cmdc.200700127. PMID 17806092.
- ↑ "The antimalarial ferroquine: from bench to clinic". Parasite 18 (3): 207–214. August 2011. doi:10.1051/parasite/2011183207. PMID 21894260.
- ↑ "Ferroquine and its derivatives: new generation of antimalarial agents". European Journal of Medicinal Chemistry 101: 534–551. August 2015. doi:10.1016/j.ejmech.2015.07.009. PMID 26188909.
- ↑ "Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue". Journal of Medicinal Chemistry 40 (23): 3715–3718. November 1997. doi:10.1021/jm970401y. PMID 9371235.
- ↑ "Ferroquine and artesunate in African adults and children with Plasmodium falciparum malaria: a phase 2, multicentre, randomised, double-blind, dose-ranging, non-inferiority study". The Lancet. Infectious Diseases 15 (12): 1409–1419. December 2015. doi:10.1016/S1473-3099(15)00079-1. PMID 26342427.
- ↑ "A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria". Malaria Journal 20 (1): 222. May 2021. doi:10.1186/s12936-021-03749-4. PMID 34011358.
 |  |
