Chemistry:Gandotinib
From HandWiki
Short description: Chemical compound
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| Routes of administration | PO |
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| Formula | C23H25ClFN7O |
| Molar mass | 469.95 g·mol−1 |
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Gandotinib (LY-2784544) is an experimental drug developed by Eli Lilly for treatment of cancer. It is a small molecule JAK2 (Janus kinase) inhibitor, with additional minor inhibition of STAT3.
In a phase I trial, 16% of patients receiving the drug developed tumor lysis syndrome.[1] A phase II trial is underway for patients with myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia, or myelofibrosis, who had failed ruxolitinib.[2][3]
References
- ↑ "Gandotinib - Eli Lilly". AdisInsight. Springer Nature Switzerland AG. http://adisinsight.springer.com/drugs/800032290.
- ↑ Clinical trial number NCT01594723 for "A Study of LY2784544 in Participants With Myeloproliferative Neoplasms" at ClinicalTrials.gov
- ↑ "Phase 2 study of gandotinib (LY2784544) in patients with myeloproliferative neoplasms". Leukemia Research 71: 82–88. August 2018. doi:10.1016/j.leukres.2018.06.014. PMID 30025280.
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