Chemistry:HT-2157
From HandWiki
Short description: Chemical compound
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| Formula | C21H13F3N2O |
| Molar mass | 366.343 g·mol−1 |
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HT-2157 (former development code SNAP-37889) is a drug which acts as a selective non-peptide antagonist for the receptor GAL-3, which is usually activated by the neuropeptide galanin. Blocking this receptor with HT-2157 produced increased serotonin release,[1] as well as producing antidepressant and anxiolytic effects in animal studies,[2] and it was also being researched for treatment of cognitive dysfunction.[3] All human clinical trials were terminated due to safety concerns however, and new GAL-3 antagonists are now being sought instead.[4]
References
- ↑ "pA2 Online". http://www.pa2online.org/abstract/abstract.jsp?abid=28301.
- ↑ "Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299". Proceedings of the National Academy of Sciences of the United States of America 102 (48): 17489–94. November 2005. doi:10.1073/pnas.0508970102. PMID 16287967.
- ↑ Kaplan AP, "Enteric-coated HT-2157 compositions and methods of their use", US patent 8277842, published January 20, 2012
- ↑ "Dart NeuroScience LLC -- Scientific Advisory Board". http://www.dartneuroscience.com/DrugPrograms.php.
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