Biology:Galanin receptor 3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Galanin receptor 3 (GAL₃) is a G-protein coupled receptor encoded by the GALR3 gene.

Function

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts

See also

• Galanin receptor

Further reading

• "Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels". The Journal of Biological Chemistry 273 (36): 23321–6. Sep 1998. doi:10.1074/jbc.273.36.23321. PMID 9722565. 
• "Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3". Journal of Neurochemistry 71 (6): 2239–51. Dec 1998. doi:10.1046/j.1471-4159.1998.71062239.x. PMID 9832121. 
• "Structural organization and chromosomal localization of three human galanin receptor genes". Annals of the New York Academy of Sciences 863: 56–63. Dec 1998. doi:10.1111/j.1749-6632.1998.tb10683.x. PMID 9928159. 
• "A polymorphism in the human GALR3 galanin receptor gene (GALNR3)". Molecular and Cellular Probes 13 (4): 325–7. Aug 1999. doi:10.1006/mcpr.1999.0254. PMID 10441207. 
• "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. Dec 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D. 
• "Elevated expression of galanin receptors in childhood neuroblastic tumors". Neuroendocrinology 75 (2): 130–8. Feb 2002. doi:10.1159/000048229. PMID 11867941. 
• "Alcoholism is associated with GALR3 but not two other galanin receptor genes". Genes, Brain and Behavior 6 (5): 473–81. Jul 2007. doi:10.1111/j.1601-183X.2006.00275.x. PMID 17083333. 
• "Determining receptor-ligand interaction of human galanin receptor type 3". Neurochemistry International 57 (7): 804–11. Dec 2010. doi:10.1016/j.neuint.2010.08.018. PMID 20817064. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-37226. 

External links

• "Galanin Receptors: GAL₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2983. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.