Chemistry:Homophthalic acid
From HandWiki
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| Names | |
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| Preferred IUPAC name
2-(Carboxymethyl)benzoic acid | |
| Other names
α-Carboxy-o-toluic acid
Carboxyphenyl acetic acid | |
| Identifiers | |
3D model (JSmol)
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| ChEMBL | |
| ChemSpider | |
| EC Number |
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PubChem CID
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| UNII | |
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| Properties | |
| C9H8O4 | |
| Molar mass | 180.159 g·mol−1 |
| Appearance | Off-white to light yellow or pale green |
| Melting point | 181 °C (358 °F; 454 K)[2] |
| Hazards | |
| GHS pictograms | 
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| GHS Signal word | Warning |
| H315, H319, H335 | |
| P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Homophthalic acid is a dicarboxylic acid with the formula C6H4(CO2H)CH2CO2H. It is a colorless solid. The compounds can be prepared by the Willgerodt reaction from 2-acetylbenzoic acid.[3]
One of the uses is in the preparation of the NSAID tesicam.
Further reading
- Use of homophthalic anhydride: Manoni, Francesco; Connon, Stephen J. (2014). "Catalytic Asymmetric Tamura Cycloadditions". Angewandte Chemie International Edition 53 (10): 2628–2632. doi:10.1002/anie.201309297. PMID 24573916.
References
- ↑ "Compound Record". http://ops.rsc.org/Compounds/Get/670357.
- ↑ "Homophthalic Acid". https://www.chemspider.com/Chemical-Structure.60010.html.
- ↑ Schwenk, Erwin; Papa, Domenick (1946). "Preparation of Aryl Aliphatic Acids by the Modified Willgerodt Reaction". The Journal of Organic Chemistry 11 (6): 798–802. doi:10.1021/jo01176a023. PMID 20282506.
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