Chemistry:Hydroxyacetylaminofluorene

From HandWiki

Hydroxyacetylaminofluorene is a derivative of 2-acetylaminofluorene used as a biochemical tool in the study of carcinogenesis.

Biochemistry

N-hydroxy-2-acetamidofluorene reductase is an enzyme that catalyzes the conversion of the carcinogen, hydroxyacetylaminofluorene to 2-acetylaminofluorene. It uses reduced nicotinamide adenine dinucleotide (NADH) as its cofactor.[1][2]

  1. REDIRECT Template:Chemical reaction

See also

References

  1. ↑ "The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver in vitro. An inducible enzymatic reaction". J. Biol. Chem. 244 (7): 1729–40. 1969. doi:10.1016/S0021-9258(18)91744-8. PMID 5780838. 
  2. ↑ "Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol". Biochem. Biophys. Res. Commun. 133 (1): 67–74. 1985. doi:10.1016/0006-291X(85)91842-X. PMID 4074379. Bibcode: 1985BBRC..133...67K. 



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