Chemistry:IBC 293
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| Formula | C10H11N3O2 |
| Molar mass | 205.217 g·mol−1 |
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IBC 293 is an experimental drug which acts as a potent and selective agonist for the Hydroxycarboxylic acid receptor 3 (GPR109B), with good selectivity over the closely related HCA2/GPR109A receptor. It is used for studying the function of this receptor, and has been shown to activate neutrophils, demonstrating a role for HCA3 in immune system function.[1][2][3]
References
- ↑ "1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b". Journal of Medicinal Chemistry 49 (4): 1227–1230. February 2006. doi:10.1021/jm051099t. PMID 16480258.
- ↑ "Nicotinic acid receptor agonists". Journal of Medicinal Chemistry 51 (24): 7653–7662. December 2008. doi:10.1021/jm800896z. PMID 18983141.
- ↑ "Activation and signaling characteristics of the hydroxy-carboxylic acid 3 receptor identified in human neutrophils through a microfluidic flow cell technique". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1872 (5). June 2025. doi:10.1016/j.bbamcr.2025.119950. PMID 40194600.
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