Biology:Hydroxycarboxylic acid receptor 3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Hydroxycarboxylic acid receptor 3 (HCA3), also known as niacin receptor 2 (NIACR2) and GPR109B,[1] is a protein which in humans is encoded by the HCAR3 gene.[2][3] HCA3, like the other hydroxycarboxylic acid receptors HCA1 and HCA2, is a Gi/o-coupled G protein-coupled receptor (GPCR).[1][4] The primary endogenous agonists of HCA3 are 3-hydroxyoctanoic acid and kynurenic acid.[1][4][5] HCA3 is also a low-affinity biomolecular target for niacin (aka nicotinic acid).[6]
References
- ↑ 1.0 1.1 1.2 "International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)". Pharmacological Reviews 63 (2): 269–90. June 2011. doi:10.1124/pr.110.003301. PMID 21454438.
- ↑ "Entrez Gene: GPR109B G protein-coupled receptor 109B". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8843.
- ↑ "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". International Immunology 5 (10): 1239–49. October 1993. doi:10.1093/intimm/5.10.1239. PMID 7505609.
- ↑ 4.0 4.1 "Hydroxycarboxylic acid receptors". International Union of Basic and Clinical Pharmacology. http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=48.
- ↑ Kapolka, NJ; Taghon, GJ; Rowe, JB; Morgan, WM; Enten, JF; Lambert, NA; Isom, DG (9 June 2020). "DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery.". Proceedings of the National Academy of Sciences of the United States of America 117 (23): 13117–13126. doi:10.1073/pnas.2000430117. PMID 32434907. Bibcode: 2020PNAS..11713117K.
- ↑ Peters, A; Krumbholz, P; Jäger, E; Heintz-Buschart, A; Çakir, MV; Rothemund, S; Gaudl, A; Ceglarek, U et al. (May 2019). "Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3.". PLOS Genetics 15 (5): e1008145. doi:10.1371/journal.pgen.1008145. PMID 31120900.
External links
- "Nicotinic Acid Receptor Family: GPR109B". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3009.
Further reading
- "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". International Immunology 5 (10): 1239–49. October 1993. doi:10.1093/intimm/5.10.1239. PMID 7505609.
- "Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor". Genomics 42 (3): 519–23. June 1997. doi:10.1006/geno.1997.4754. PMID 9205127.
- "Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3". Journal of the Peripheral Nervous System 7 (2): 87–95. June 2002. doi:10.1046/j.1529-8027.2002.02014.x. PMID 12090300.
- "Molecular identification of high and low affinity receptors for nicotinic acid". The Journal of Biological Chemistry 278 (11): 9869–74. March 2003. doi:10.1074/jbc.M210695200. PMID 12522134.
- "PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect". Nature Medicine 9 (3): 352–5. March 2003. doi:10.1038/nm824. PMID 12563315.
- "Molecular identification of nicotinic acid receptor". Biochemical and Biophysical Research Communications 303 (1): 364–9. March 2003. doi:10.1016/S0006-291X(03)00342-5. PMID 12646212.
- "Large-scale identification of human genes implicated in epidermal barrier function". Genome Biology 8 (6): R107. 2007. doi:10.1186/gb-2007-8-6-r107. PMID 17562024.
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