Chemistry:Inidascamine

From HandWiki

Inidascamine (INN; developmental code names RL-007, FSV7-007) is an experimental drug which is under development for the treatment of cognitive impairment associated with schizophrenia (CIAS).[1][2][3][4][5][6] It is taken orally.[1][6] The drug is said to act on the cholinergic, NMDA, and GABAB receptor systems.[1][4][6] Inidascamine is being developed by Recognify Life Sciences and atai Life Sciences.[1][2] It was discovered via screening of compounds for effects on synaptic plasticity and cognition.[6] The drug shows structural similarities to phenethylamines and amphetamines.[7]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 "RL 007". 10 June 2024. https://adisinsight.springer.com/drugs/800061925. 
  2. ↑ 2.0 2.1 "Delving into the Latest Updates on RL-007 with Synapse". 23 January 2025. https://synapse.patsnap.com/drug/30edcb9560244b7ebff63c21a1d860fa. 
  3. ↑ "New directions in psychiatric drug development: promising therapeutics in the pipeline". Expert Opinion on Drug Discovery 18 (8): 835–850. 2023. doi:10.1080/17460441.2023.2224555. PMID 37352473. 
  4. ↑ 4.0 4.1 "Definition, assessment and treatment of cognitive impairment associated with schizophrenia: expert opinion and practical recommendations". Frontiers in Psychiatry 15. 2024. doi:10.3389/fpsyt.2024.1451832. PMID 39371908. 
  5. ↑ "Current emerging therapeutic targets and clinical investigational agents for schizophrenia: Challenges and opportunities". Medicinal Research Reviews 45 (2): 755–787. March 2025. doi:10.1002/med.22086. PMID 39300769. 
  6. ↑ 6.0 6.1 6.2 6.3 Donello JE, Walker GA, Schweighoffer F, and Pando MP. Abstract Number: 149. RL-007, a novel oral neuromodulator, enhances synaptic plasticity and cognition in non-clinical models. American College of Neuropsychopharmacology (ACNP) annual meeting. December 5, 2023. https://ir.atai.life/static-files/06c60339-e93c-42fc-9323-c0e38e83f86e
  7. ↑ "2-Amino-3-hydroxy-3-(pyridin-4-yl)-1-(pyrrolidin-1-yl)propan-1-one, (2R,3S)-". https://pubchem.ncbi.nlm.nih.gov/compound/11535990. 



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